Andrews J S, Sahgal A
Pharmacol Biochem Behav. 1984 Nov;21(5):715-9. doi: 10.1016/s0091-3057(84)80008-8.
The effects of intracerebroventricular (ICV) administration of thyrotropin releasing hormone (TRH, 1 and 50 micrograms) were assessed on a two-choice visual discrimination task. The data were analysed using signal detection theory techniques in order to test for changes in cognitive and response factors. No significant changes in performance were observed. In a second experiment, the effects of TRH (100 micrograms ICV) on performance were compared with amphetamine (AMP, 1 mg/kg, intra-peritoneally, IP) and a metabolite of TRH, histidyl-proline diketopiperazine (DKP, 100 micrograms ICV). No significant effects on performance as measured by standard indices were observed. However, both TRH and AMP, but not DKP, significantly increased perseverative responding on one lever with respect to saline. In keeping with recent evidence, it is concluded that the traditional non-parametric signal detection parameters of sensitivity and bias are insensitive to certain strategies. Possible mechanisms for the perseveration of responding, and its relationship to stereotypic behaviour, are discussed in the light of the known effects of each compound on dopaminergic systems.
评估了脑室内（ICV）注射促甲状腺激素释放激素（TRH，1微克和50微克）对双选视觉辨别任务的影响。为了测试认知和反应因素的变化，使用信号检测理论技术对数据进行了分析。未观察到性能的显著变化。在第二个实验中，将TRH（100微克ICV）对性能的影响与苯丙胺（AMP，1毫克/千克，腹腔注射，IP）和TRH的一种代谢产物组氨酰-脯氨酸二酮哌嗪（DKP，100微克ICV）进行了比较。通过标准指标测量，未观察到对性能的显著影响。然而，与生理盐水相比，TRH和AMP均显著增加了在一个杠杆上的持续反应，而DKP则没有。根据最近的证据得出结论，传统的敏感性和偏差非参数信号检测参数对某些策略不敏感。根据每种化合物对多巴胺能系统的已知作用，讨论了反应持续存在的可能机制及其与刻板行为的关系。
