Narita Kentaro, Kobayashi Hiroki, Abe Yoshiaki, Kitadate Hiroaki, Takeuchi Masami, Matsue Kosei
Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, 929 Higashi-chou, Kamogawa-shi, Chiba, 296-8602, Japan.
Int J Hematol. 2018 Oct;108(4):371-374. doi: 10.1007/s12185-018-2489-0. Epub 2018 Jul 5.
We examined the association of residual bone-marrow plasma cells (PCs) and International Myeloma Working Group (IMWG) response assessment in light-chain-only multiple myeloma (LCMM) and intact immunoglobulin multiple myeloma (IIMM) using multicolour flow cytometry (MFC). We identify considerable differences in bone-marrow neoplastic PC levels between IIMM and LCMM for the same IMWG response categories. Furthermore, even in the same IMWG response category, residual neoplastic PC levels differed considerably over a logarithmic scale range However, normalization of the free light-chain ratio is associated with deeper response (< 10) in LCMM, but not in IIMM. Our observations highlight the importance of quantifying BM PC by MFC for response assessment, especially for relapsed disease when there is suspected discrepancy in paraprotein levels and disease progression.
我们使用多色流式细胞术（MFC）研究了仅轻链型多发性骨髓瘤（LCMM）和完整免疫球蛋白型多发性骨髓瘤（IIMM）中残余骨髓浆细胞（PC）与国际骨髓瘤工作组（IMWG）反应评估之间的关联。我们发现，对于相同的IMWG反应类别，IIMM和LCMM的骨髓肿瘤性PC水平存在显著差异。此外，即使在相同的IMWG反应类别中，残余肿瘤性PC水平在对数尺度范围内也存在很大差异。然而，游离轻链比值的正常化与LCMM中更深的反应（<10）相关，但与IIMM无关。我们的观察结果强调了通过MFC定量骨髓PC以进行反应评估的重要性，特别是对于复发疾病，当怀疑副蛋白水平和疾病进展存在差异时。
