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甲状腺乳头状癌中SLC5A5和SLC2A家族基因的mRNA表达：癌症基因组图谱分析

mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas.

作者信息

Suh Sunghwan, Kim Yun Hak, Goh Tae Sik, Jeong Dae Cheon, Lee Chi Seung, Jang Jeon Yeob, Cha Wonjae, Han Myoung Eun, Kim Seong Jang, Kim In Joo, Pak Kyoungjune

机构信息

Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Korea.

出版信息

Yonsei Med J. 2018 Aug;59(6):746-753. doi: 10.3349/ymj.2018.59.6.746.

DOI:10.3349/ymj.2018.59.6.746
PMID:29978611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6037592/
Abstract

PURPOSE

The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for ¹⁸F-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (¹³¹I) uptake in whole-body radioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients.

MATERIALS AND METHODS

The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expression data for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1-3), glucose-6-phosphate dehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1-4) mRNA were collected.

RESULTS

Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4 mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCs with higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival.

CONCLUSION

Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basis for the management of PTC with negative WBS using ¹⁸F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA was associated with less PTC recurrence, but not with deaths.

摘要

目的

本研究调查了信使核糖核酸（mRNA）表达在甲状腺乳头状癌（PTC）患者的¹⁸F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）中的FDG摄取以及全身放射性碘扫描（WBS）中的放射性碘（¹³¹I）摄取方面的动力学及预后作用。

材料与方法

从基因组数据共享数据门户下载原始数据和处理后的数据。收集钠/碘同向转运体（溶质载体家族5成员5，SLC5A5）、己糖激酶（HK1 - 3）、葡萄糖-6-磷酸脱氢酶（G6PD）和葡萄糖转运体（溶质载体家族2，SLC2A1 - 4）mRNA的表达数据。

结果

SLC5A5 mRNA的表达与SLC2A1 mRNA呈负相关，与SLC2A4 mRNA呈正相关。在具有BRAF突变的PTC中，SLC2A1、SLC2A3、HK2和HK3 mRNA的表达高于无BRAF突变的PTC。无BRAF突变的PTC中SLC5A5、SLC2A4、HK1和G6PD mRNA的表达较低。SLC5A5 mRNA表达较高的PTC患者无病生存期更优，但与总生存期无关。

结论

SLC5A5 mRNA的表达与SLC2A1 mRNA呈负相关。这一发现为使用¹⁸F-FDG PET扫描对WBS阴性的PTC进行管理提供了分子基础。此外，SLC5A5 mRNA的高表达与PTC复发较少相关，但与死亡无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/dd57e81e3392/ymj-59-746-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/bc8b8aa51f27/ymj-59-746-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/4595a55b4a5f/ymj-59-746-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/aa245b9e77a5/ymj-59-746-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/dcfa0aa786a5/ymj-59-746-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/dd57e81e3392/ymj-59-746-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/bc8b8aa51f27/ymj-59-746-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/4595a55b4a5f/ymj-59-746-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/aa245b9e77a5/ymj-59-746-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/dcfa0aa786a5/ymj-59-746-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ce8/6037592/dd57e81e3392/ymj-59-746-g005.jpg

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