School of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Nat Prod Rep. 2019 Jan 1;36(1):108-121. doi: 10.1039/c8np00034d. Epub 2018 Jul 6.
Covering: up to May 2018The verticillene family of 6,12-membered ring-fused diterpenes are found in plants, liverworts, corals and insects. Carbocations derived from verticillene hydrocarbons are central intermediates in the biosynthesis of the taxane and the phomactin families of polycyclic natural products. This perspective delineates these unique biosynthetic interrelationships, which are reinforced by recent biomimetic synthesis investigations, alongside quantum chemical calculations and targeted engineering studies of the taxadiene synthase (TXS) cascade.
截至 2018 年 5 月
具有 6 个、12 个环的倍半萜Verticillene 家族存在于植物、苔类植物、珊瑚和昆虫中。Verticillene 碳氢化合物衍生的碳正离子是紫杉烷和多环天然产物 Phomactin 家族生物合成的中心中间体。本文通过最近的仿生合成研究、量子化学计算以及紫杉二烯合酶 (TXS) 级联的靶向工程研究，阐述了这些独特的生物合成关系。
