T细胞原淋巴细胞白血病：一项临床与免疫学研究。

T-cell prolymphocytic leukaemia: a clinical and immunological study.

作者信息

Lauria F, Foa R, Raspadori D, Motta M R, Tazzari P L, Biagini G, Preda P, Algeri R, Tura S

出版信息

Scand J Haematol. 1985 Sep;35(3):319-24. doi: 10.1111/j.1600-0609.1985.tb01712.x.

DOI:10.1111/j.1600-0609.1985.tb01712.x

Abstract

2 cases of T-cell prolymphocytic leukaemia (T-PLL) were investigated for their reactivity with a series of monoclonal antibodies (MoAbs) as well as for the cytochemical expression and functional activity of the pathological cells. Both patients showed morphological (large cells with abundant cytoplasm and eccentric and irregularly shaped nucleus with large and prominent nucleoli) and clinical (high leucocyte count and splenomegaly) features typical of T-PLL. The cells from 1 patient expressed a helper/inducer phenotype (T4+, T8-) and were reactive with the anti-Tac (interleukin-2 receptor) MoAb, while the other case co-expressed both the T4 and the T8 antigens. The response to phytohaemagglutinin and the natural killer activity (assessed by 51chromium release) were significantly reduced in both cases, while the helper capacity, tested in a pokeweed mitogen-driven system, was maintained only in the 1st case. This latter case which expressed a more mature phenotype (T4+, T8-) responded well to chemotherapy.

摘要

对2例T细胞幼淋巴细胞白血病（T-PLL）患者进行了研究，检测其与一系列单克隆抗体（MoAb）的反应性以及病理细胞的细胞化学表达和功能活性。两名患者均表现出T-PLL典型的形态学（细胞大，胞质丰富，核偏心且形状不规则，核仁大且明显）和临床特征（白细胞计数高和脾肿大）。其中1例患者的细胞表达辅助/诱导表型（T4+，T8-），并与抗Tac（白细胞介素-2受体）MoAb反应，而另一例同时表达T4和T8抗原。两例患者对植物血凝素的反应和自然杀伤活性（通过51铬释放评估）均显著降低，而在商陆有丝分裂原驱动系统中检测的辅助能力仅在第一例中得以维持。后一例表现出更成熟的表型（T4+，T8-），对化疗反应良好。