a Department of Medicine, Division of Hematology-Oncology , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.
b Department of Health Sciences and Technology , Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University , Seoul , Korea.
Leuk Lymphoma. 2019 Feb;60(2):317-325. doi: 10.1080/10428194.2018.1480772. Epub 2018 Jul 6.
Extranodal natural killer/T-cell lymphoma (ENKTL) is associated with Epstein-Barr virus (EBV) infection, a common cause of hemophagocytosis. As interleukin-18 (IL18) is related with hemophagocytosis, we measured serum IL18 and IL18-related cytokines of newly diagnosed patients with ENKTL (N = 114) to investigate the role as a biomarker for hemophagocytosis and determine the prognosis of ENKTL. The median value of serum IL18 was 20.5 pg/mL (1.23-2021.81 pg/mL). The high IL18 group (≥20.5 pg/mL) was associated with stage III/IV, the presence of hemophagocytosis and poor treatment outcome. Serum IL18 showed significant positive correlations with TNFα, IFNγ, and IP10. Overall survival was significantly different between the high and low IL18 groups (p < .001), and high serum IL18 was independently prognostic for survival in the multivariate analysis. In conclusion, serum IL18 levels may be associated with the hemophagocytosis and poor survival outcomes in patients with ENKTL.
结外自然杀伤/T 细胞淋巴瘤（ENKTL）与 EBV 感染相关，后者是噬血细胞现象的常见病因。由于白细胞介素-18（IL-18）与噬血细胞现象有关，我们检测了新诊断的 ENKTL 患者（N=114）的血清 IL-18 和与 IL-18 相关的细胞因子，以研究其作为噬血细胞现象生物标志物的作用，并确定 ENKTL 的预后。血清 IL-18 的中位数为 20.5pg/mL（1.23-2021.81pg/mL）。IL-18 水平较高组（≥20.5pg/mL）与 III/IV 期、噬血细胞现象和治疗效果差相关。血清 IL-18 与 TNF-α、IFN-γ和 IP-10 呈显著正相关。高 IL-18 组和低 IL-18 组的总生存率有显著差异（p<0.001），多因素分析显示高血清 IL-18 是独立的生存预后因素。总之，血清 IL-18 水平可能与 ENKTL 患者的噬血细胞现象和不良生存结局相关。
