Simpson Emily, Brown Heather L
At the time this article was written, Emily Simpson was a student in the PA program at Mercer University in Atlanta, Ga. She now practices urgent care medicine with Georgia Emergency Associates in Savannah, Ga. Heather L. Brown is an adjunct assistant professor in the PA program at Mercer University. The authors have disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2018 Aug;31(8):15-19. doi: 10.1097/01.JAA.0000541477.24116.8d.
This article reviews the cause, clinical presentation, diagnostic methods, and management of osteosarcoma, the most common primary bone tumor and third most common cancer among children and adolescents. In the 1970s, the introduction of adjuvant chemotherapy following tumor resection improved overall 10-year survival from 30% to about 50% of patients. However, since that change in management strategy, the survival rate has since plateaued, with no improvement in overall 10-year survival since the 1990s. A better understanding of this disease is the first step to help improve these numbers.
本文综述了骨肉瘤的病因、临床表现、诊断方法及治疗，骨肉瘤是儿童和青少年中最常见的原发性骨肿瘤，也是第三大常见癌症。20世纪70年代，肿瘤切除术后引入辅助化疗使患者的10年总生存率从30%提高到了约50%。然而，自管理策略发生这一变化以来，生存率一直处于平稳状态，自20世纪90年代以来，10年总生存率没有提高。更好地了解这种疾病是帮助改善这些数据的第一步。
