Di Jia-Yin, Dai Meng-Lu, Zhang Zong-Xin
Clinical Laboratory, Department of Outpatient, Huzhou University Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou, P.R. China.
Medicine (Baltimore). 2018 Jul;97(27):e11236. doi: 10.1097/MD.0000000000011236.
Previous studies suggested an association between K121Q (rs1044498 C > A) in ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) gene and the risk of coronary heart disease (CHD), but the results have been inconsistent. In this study, we performed a meta-analysis of several trials to systematically summarize their potential association.
Relevant articles were identified by searching electronic databases for studies published prior to March 2018. We carefully reviewed published studies on ENPP1 genetic polymorphism in relation to CHD susceptibility. The data extracted from selected high-quality studies were analyzed using STATA statistical software (StataCorp LP, College Station, TX, USA).
Nine eligible studies which contained a combined total of 1547 CHD cases and 2213 healthy controls were chosen in the present meta-analysis. Our results indicated that K121Q strongly correlated with increased risk of CHD. The subgroup analysis on race, sample source, disease type, sex, age, and genotype showed that in Caucasians, K121Q strongly correlated with increased risk of CHD, but no difference was found in Chinese. Both single factor and multiple factor regression showed that race, sample origin, disease type, sex, age, and genotype were not the source of heterogeneity.
Our meta-analysis revealed that the K121Q (rs1044498 C > A) in the ENPP1 gene is a risk factor for CHD.
先前的研究表明，胞外核苷酸焦磷酸酶磷酸二酯酶1（ENPP1）基因中的K121Q（rs1044498 C>A）与冠心病（CHD）风险之间存在关联，但结果并不一致。在本研究中，我们对多项试验进行了荟萃分析，以系统总结它们之间的潜在关联。
通过检索电子数据库，找出2018年3月之前发表的相关研究。我们仔细审查了已发表的关于ENPP1基因多态性与冠心病易感性的研究。从选定的高质量研究中提取的数据使用STATA统计软件（美国德克萨斯州大学站StataCorp LP公司）进行分析。
本荟萃分析选取了9项符合条件的研究，共纳入1547例冠心病患者和2213例健康对照。我们的结果表明，K121Q与冠心病风险增加密切相关。种族、样本来源、疾病类型、性别、年龄和基因型的亚组分析表明，在白种人中，K121Q与冠心病风险增加密切相关，但在中国人群中未发现差异。单因素和多因素回归分析均显示，种族、样本来源、疾病类型、性别、年龄和基因型均不是异质性的来源。
我们的荟萃分析表明，ENPP1基因中的K121Q（rs1044498 C>A）是冠心病的一个危险因素。
