主动脉弓手术中4种主要脑保护策略的效果：一项使用Stata进行系统评价和网状Meta分析的方案
Effects of 4 major brain protection strategies during aortic arch surgery: A protocol for a systematic review and network meta-analysis using Stata.
作者信息
Fan Shulei, Wang Daoxing, Wu Chun, Pan Zhengxia, Li Yonggang, An Yong, Li Hongbo, Wang Gang, Dai Jiangtao, Wang Quan
机构信息
Chongqing Medical University Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Pediatrics, Chongqing Medical University, Chongqing, China.
出版信息
Medicine (Baltimore). 2018 Jul;97(27):e11448. doi: 10.1097/MD.0000000000011448.
BACKGROUND
Reliable brain protection during aortic arch surgery remains a formidable surgical challenge. Various cerebral protection techniques have been used in the clinic; however, there is no consensus regarding which strategy is best. We will perform a network meta-analysis (NMA) focusing on the permanent neurological deficits (PND) and perioperative mortality associated with 4 major brain protection strategies used during aortic arch surgery.
METHODS
We will perform a literature search of MEDLINE, EMBASE, Cochrane Library, and PubMed databases. The primary outcomes of interest in this analysis will be PND and perioperative mortality. Inconsistencies in the NMA will be evaluated with global and local approaches. Network rank and surface under the cumulative ranking curve (SUCRA) analyses will be performed to evaluate and identify the superiority of different brain protection techniques.
RESULTS
This study is ongoing and will be submitted to a peer-reviewed journal for consideration of publication.
CONCLUSIONS
Our study will increase understanding of 4 major brain protection strategies during aortic arch surgery and be helpful to clinicians using NMA in their studies.
背景
在主动脉弓手术期间实现可靠的脑保护仍然是一项艰巨的外科挑战。临床上已采用多种脑保护技术；然而，对于哪种策略最佳尚无共识。我们将进行一项网络荟萃分析（NMA），重点关注与主动脉弓手术期间使用的4种主要脑保护策略相关的永久性神经功能缺损（PND）和围手术期死亡率。
方法
我们将对MEDLINE、EMBASE、Cochrane图书馆和PubMed数据库进行文献检索。本分析中感兴趣的主要结局将是PND和围手术期死亡率。将采用全局和局部方法评估NMA中的不一致性。将进行网络排名和累积排名曲线下面积（SUCRA）分析，以评估和确定不同脑保护技术的优越性。
结果
本研究正在进行中，将提交给同行评审期刊以供考虑发表。
结论
我们的研究将增进对主动脉弓手术期间4种主要脑保护策略的理解，并有助于临床医生在其研究中使用NMA。
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