Ogata T, Endo K
Cancer. 1984 Oct 15;54(8):1635-44. doi: 10.1002/1097-0142(19841015)54:8<1635::aid-cncr2820540827>3.0.co;2-u.
Thirty-five peripheral carcinomas of human lungs were morphologically examined in comparison with the bronchiolar nonciliated epithelium. Clara cell granules were found not only in 21 cases of papillary adenocarcinoma, including three of classical bronchiolo-alveolar carcinoma, but also two of acinar and four of solid carcinoma. The granules of tumor cells were identical to those of bronchiolar nonciliated cells on histochemical and ultrastructural levels. Most granules consisted of a monotonous and finely granular matrix, but there were variants containing fingerprint-like lamellae and small vesicles. These variants were also found in nonciliated cells of normal bronchiolar epithelium. The amount of granules was related to the degree of tumor differentiation. It is suggested that most peripheral carcinomas of the lungs have a potential for Clara cell differentiation, irrespective of whether they exhibit any histologic appearances.
对35例人肺外周癌进行了形态学检查，并与细支气管无纤毛上皮进行比较。不仅在21例乳头状腺癌（包括3例经典型细支气管肺泡癌）中发现了克拉拉细胞颗粒，在2例腺泡癌和4例实体癌中也发现了该颗粒。在组织化学和超微结构水平上，肿瘤细胞的颗粒与细支气管无纤毛细胞的颗粒相同。大多数颗粒由单一的细颗粒基质组成，但也有含有指纹样薄片和小泡的变体。这些变体在正常细支气管上皮的无纤毛细胞中也有发现。颗粒的数量与肿瘤分化程度有关。提示大多数肺外周癌具有克拉拉细胞分化的潜能，无论其表现出何种组织学形态。
