Moudgil Aman Dev, Singla Lachhman Das
Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
J Med Primatol. 2018 Dec;47(6):388-392. doi: 10.1111/jmp.12358. Epub 2018 Jul 6.
This study aimed to assess Trichuris species infection and evaluate the anthelmintic efficacy of fenbendazole and ivermectin against natural trichurid infections in non-human primates (NHPs), kept at Mahendra Chaudhury (MC) Zoological Park, Chhatbir, India.
Molecular confirmation of Trichuris infection was carried out using polymerase chain reaction targeting internal transcribed spacer sequences, and anthelmintic efficacy was assessed by fecal egg count reduction test, respectively.
A 710 base pair product confirmed Trichuris species infection in NHPs. Fenbendazole, 10 mg/kg body weight orally for 5 consecutive days and ivermectin, 100 μg/kg body weight orally for 3 alternate days proved effective and showed a maximum fecal egg reduction of 99.20% and 100% (P < .05) at day 7 post-treatment.
This study highlighted the molecular confirmation of Trichuris species in non-human primates and its management using fenbendazole and ivermectin.
本研究旨在评估毛首鞭形线虫属物种感染情况，并评价芬苯达唑和伊维菌素对印度恰特比尔马亨德拉·乔杜里（MC）动物园圈养的非人灵长类动物（NHPs）自然感染毛首鞭形线虫的驱虫效果。
分别采用针对内转录间隔区序列的聚合酶链反应进行毛首鞭形线虫感染的分子确认，并通过粪便虫卵计数减少试验评估驱虫效果。
一段710个碱基对的产物证实了非人灵长类动物感染了毛首鞭形线虫属物种。芬苯达唑，按体重10毫克/千克口服，连续5天；伊维菌素，按体重100微克/千克口服，每隔1天给药1次，连续3次，结果证明有效，在治疗后第7天粪便虫卵减少率最高分别达99.20%和100%（P < 0.05）。
本研究强调了非人灵长类动物中毛首鞭形线虫属物种的分子确认以及使用芬苯达唑和伊维菌素对其进行管理。
