Department of Social Nutrition, Emilia de Jesus Ferreiro Nutrition School, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
Department of Pediatrics, New York University School of Medicine, New York, New York, USA.
Nutrition. 2018 Nov;55-56:91-98. doi: 10.1016/j.nut.2018.03.050. Epub 2018 Mar 29.
This study aimed to evaluate the association between nightly, napping, and 24-h sleep duration throughout pregnancy and birth weight z-score among nulli- and multiparous women.
Nightly,napping, and 24-h sleep duration and birth weight z-score (calculated on thebasis of the International Fetal and Newborn Growth Consortium for the 21st century standards) were studied in a cohort of 176 pregnant women from Brazil. Linear mixed-effect analyses were performed to assess the longitudinal evolution of sleep duration and the best unbiased linear predictors of the random coefficients were estimated. The best unbiased linear predictor estimates of sleep duration intercept and slope were included in the linear regression models with birth weight z-score as the outcome.
The mean hours of nightly sleep decreased during pregnancy in nulliparous women (β = -0.55; 95% confidence interval [CI], -0.83 to -0.27) but the decrease was not statistically significant in multiparous women (β = -0.19; 95% CI, -0.30 to 0.01). Twenty-four hour sleep duration decreased during pregnancy in both multiparous (β = -0.50; 95% CI, -0.76 to -0.25) and nulliparous women (β = 0.77; 95% CI, -1.06 to -0.48). Napping sleep duration did not change in either group. Among the nulliparous women, both first-trimester 24-h sleep duration and its change throughout pregnancy were inversely associated with birth weight (β = -0.44; 95% CI, -0.68 to -0.21; β = -1.75; 95% CI, -3.17 to -0.30, respectively). No associations were detected in multiparous women for nightly and napping sleep duration.
Nulliparous women with greater decreases in sleep duration throughout their pregnancy gave birth to newborns with lower birth weight z-scores.
本研究旨在评估孕妇夜间、小睡和 24 小时睡眠时间与单胎和多胎孕妇新生儿出生体重 z 评分的关系。
对来自巴西的 176 名孕妇的夜间、小睡和 24 小时睡眠时间和新生儿出生体重 z 评分（基于 21 世纪国际胎儿和新生儿生长协会标准计算）进行研究。采用线性混合效应分析评估睡眠时间的纵向变化，并估计随机系数的最佳无偏线性预测值。睡眠时间截距和斜率的最佳无偏线性预测值估计值被纳入以出生体重 z 评分作为结果的线性回归模型。
单胎孕妇的夜间睡眠时间在孕期逐渐减少（β=-0.55；95%置信区间，-0.83 至-0.27），但多胎孕妇的减少无统计学意义（β=-0.19；95%置信区间，-0.30 至 0.01）。多胎（β=-0.50；95%置信区间，-0.76 至-0.25）和单胎（β=0.77；95%置信区间，-1.06 至-0.48）孕妇的 24 小时睡眠时间在孕期逐渐减少。两组孕妇的小睡睡眠时间均无变化。在单胎孕妇中，整个孕期的 24 小时睡眠时间及其变化均与出生体重呈负相关（β=-0.44；95%置信区间，-0.68 至-0.21；β=-1.75；95%置信区间，-3.17 至-0.30）。多胎孕妇的夜间和小睡睡眠时间与新生儿出生体重无相关性。
孕期睡眠时间减少较多的单胎孕妇所生新生儿出生体重 z 评分较低。
