Murata Tsuyoshi, Kyozuka Hyo, Fukuda Toma, Yasuda Shun, Yamaguchi Akiko, Morokuma Seiichi, Sato Akiko, Ogata Yuka, Shinoki Kosei, Hosoya Mitsuaki, Yasumura Seiji, Hashimoto Koichi, Nishigori Hidekazu, Fujimori Keiya
Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
BMC Pregnancy Childbirth. 2021 Apr 12;21(1):295. doi: 10.1186/s12884-021-03670-3.
The adequate maternal sleep duration required for favorable obstetric outcomes is unknown. We evaluated the association between maternal sleep duration and low birth weight infants, small for gestational age infants, and macrosomia.
Participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study, with singleton pregnancies after 22 weeks, who gave birth between 2011 and 2014 were enrolled and categorized into five groups according to maternal sleep duration during pregnancy: < 6.0 h, 6.0-7.9 h, 8.0-8.9 h, 9.0-9.9 h, and 10.0-12.0 h. We evaluated the association between maternal sleep duration and the incidence of low birth weight infants (< 2500 g), very low birth weight infants (< 1500 g), small for gestational age infants, and macrosomia (> 4000 g), with women with maternal sleep duration of 6.0-7.9 h as the reference, using a multiple logistic regression model.
In total, 82,171 participants were analyzed. The adjusted odds ratios (95% confidence intervals) for low birth weight infants in women with maternal sleep duration of 9.0-9.9 h and 10.0-12.0 h and for small for gestational age infants in women with maternal sleep duration of 9.0-9.9 h were 0.90 (0.83-0.99), 0.86 (0.76-0.99), and 0.91 (0.82-0.99), respectively, before adjusting for excessive gestational weight gain. No significant association was observed between maternal sleep duration and these outcomes after adjusting for excessive gestational weight gain. Among women with appropriate gestational weight gain, the adjusted odds ratios (95% confidence intervals) for low birth weight infants and for small for gestational age infants with sleep duration of 9.0-9.9 h were 0.88 (0.80-0.97) and 0.87 (0.78-0.97), respectively.
Maternal sleep duration of 9.0-9.9 h was significantly associated with the decreased incidence of low birth weight infants and small for gestational age infants in pregnant women with appropriate gestational weight gain, compared with that of 6.0-7.9 h. Care providers should provide proper counseling regarding the association between maternal sleep duration and neonatal birth weight and suggest comprehensive maternal lifestyle modifications to prevent low birth weight and small for gestational age infants.
分娩结局良好所需的充足孕期睡眠时间尚不清楚。我们评估了孕期睡眠时间与低体重儿、小于胎龄儿和巨大儿之间的关联。
纳入日本环境与儿童研究（一项全国性出生队列研究）中2011年至2014年期间分娩的单胎妊娠且孕22周后入组的参与者，并根据孕期母亲睡眠时间分为五组：<6.0小时、6.0 - 7.9小时、8.0 - 8.9小时、9.0 - 9.9小时和10.0 - 12.0小时。以孕期母亲睡眠时间为6.0 - 7.9小时的女性为参照，使用多因素逻辑回归模型评估孕期睡眠时间与低体重儿（<2500克）、极低体重儿（<1500克）、小于胎龄儿和巨大儿（>4000克）发生率之间的关联。
总共分析了82,171名参与者。在未对孕期体重过度增加进行校正时，孕期母亲睡眠时间为9.0 - 9.9小时和10.0 - 12.0小时的女性中低体重儿的校正比值比（95%置信区间）以及孕期母亲睡眠时间为9.0 - 9.9小时的女性中小于胎龄儿的校正比值比分别为0.90（0.83 - 0.99）、0.86（0.
