Department of Nutrition, Food Safety and Toxicology, West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu 610041, Sichuan, China.
Department of Nutrition, Food Safety and Toxicology, West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu 610041, Sichuan, China.
Psychiatry Res. 2018 Sep;267:506-515. doi: 10.1016/j.psychres.2018.05.049. Epub 2018 May 23.
Copper (Cu) has been associated with mental disorders such as autism and epilepsy. So far, publications evaluating copper levels in patients with depressive disorder showed conflicted results. To derive a comprehensive estimation of the relationship between body burden of copper and depressive disorder and explore the possible role of copper in mental health, we performed a systematic review and meta-analysis. Relevant published data were obtained by searching PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM) before October 10, 2017. Weighted mean difference (WMD) with a 95% confidence interval (95%CI) was calculated using STATA 12.0. A total of 21 studies with 1487 patients and 943 controls were collected in this meta-analysis. Pooled analysis found that patients with depression had higher blood levels of copper than the controls without depression, while there was no difference of copper content in hair between the two groups. Subgroup analysis suggested that age had influence on the relationship between copper and depression. No evidence of publication bias was observed. This meta-analysis suggests that increased levels of blood copper might be associated with depressive disorder and therefore the possible role of copper as a biomarker of depression.
铜（Cu）与自闭症和癫痫等精神疾病有关。到目前为止，评估抑郁症患者铜水平的出版物显示出相互矛盾的结果。为了全面评估体内铜负荷与抑郁症之间的关系，并探讨铜在精神健康中的可能作用，我们进行了系统评价和荟萃分析。相关的已发表数据通过在 2017 年 10 月 10 日之前搜索 PubMed、Web of Science、中国国家知识基础设施（CNKI）和中国生物医学数据库（CBM）获得。使用 STATA 12.0 计算加权均数差值（WMD）和 95%置信区间（95%CI）。本荟萃分析共纳入 21 项研究，共纳入 1487 例抑郁症患者和 943 例对照。汇总分析发现，抑郁症患者的血铜水平高于无抑郁症的对照组，而两组的头发铜含量无差异。亚组分析表明，年龄对铜与抑郁之间的关系有影响。未观察到发表偏倚的证据。本荟萃分析表明，血铜水平升高可能与抑郁症有关，因此铜可能作为抑郁症的生物标志物。
