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妊娠高血压疾病与黑人女性的早产率。

Hypertensive Disorders of Pregnancy and Preterm Birth Rates among Black Women.

机构信息

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Department of Pediatrics, University of California, San Diego, La Jolla, California.

出版信息

Am J Perinatol. 2019 Jan;36(2):148-154. doi: 10.1055/s-0038-1660461. Epub 2018 Jul 6.

Abstract

OBJECTIVE

The objective of this study was to investigate the role of gestational hypertension (gHTN) and chronic hypertension (cHTN) on rates of preterm birth (PTB) among black women.

STUDY DESIGN

Singleton live births between 20 and 44 weeks' gestation among black women in California from 2007 to 2012 were used for analysis. Risk of PTB by subtype and gestational age among women with cHTN or gHTN, including preeclampsia, was calculated via Poisson's logistic regression modeling. Risks were adjusted for maternal factors associated with increased risk of PTB.

RESULTS

A total of 154,950 women met the inclusion criteria. Of the 5,948 women in the sample with cHTN, 26.2% delivered preterm; for the 11,728 women with gHTN, 21.6% delivered preterm. Women with gHTN or cHTN had a higher risk of medically indicated and spontaneous PTB, both at less than 32 and 32 to 36 weeks, when compared with nonhypertensive women (adjusted relative risks [aRRs]: 3.4-11.6). Women with superimposed preeclampsia had higher risks of spontaneous (aRR: 2.8, 95% confidence interval [CI]: 2.3-3.4) and medically indicated PTB (aRR: 2.8, 95% CI: 2.0-3.8), especially PTB < 32 weeks, when compared with women with preeclampsia.

CONCLUSION

Among black women, superimposed preeclampsia increased the risk for spontaneous and medically indicated PTB, especially PTB < 32 weeks.

摘要

目的

本研究旨在探讨妊娠期高血压(gHTN)和慢性高血压(cHTN)对黑人女性早产(PTB)发生率的影响。

研究设计

本研究使用了 2007 年至 2012 年间加利福尼亚州黑人女性 20 至 44 周龄单胎活产的妊娠数据进行分析。通过泊松逻辑回归模型计算患有 cHTN 或 gHTN(包括子痫前期)的女性在早产亚组和孕龄中的 PTB 风险。通过调整与 PTB 风险增加相关的产妇因素来调整风险。

结果

共有 154950 名女性符合纳入标准。在样本中,5948 名患有 cHTN 的女性中,26.2%早产;11728 名患有 gHTN 的女性中,21.6%早产。与非高血压女性相比,患有 gHTN 或 cHTN 的女性在孕龄小于 32 周和 32-36 周时,有更高的医源性和自发性 PTB 风险(调整后的相对风险 [aRR]:3.4-11.6)。患有重叠性子痫前期的女性有更高的自发性(aRR:2.8,95%置信区间 [CI]:2.3-3.4)和医源性 PTB 风险(aRR:2.8,95%CI:2.0-3.8),尤其是与患有子痫前期的女性相比,孕龄小于 32 周时。

结论

在黑人女性中,重叠性子痫前期增加了自发性和医源性 PTB 的风险,尤其是孕龄小于 32 周时。

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