Doualla-Bija Marie, Lobe Batchama Yonathan, Moutchia-Suh Jude, Ama Moor Vicky Joceline, Kamdem Félicité, Lekpa Fernando Kemta, Luma Namme Henry
Faculty of Medicine and Biomedical Sciences UY I, Yaoundé, Cameroon; General Hospital, Douala, Cameroon.
Faculty of Medicine and Biomedical Sciences UY I, Yaoundé, Cameroon.
Diabetes Metab Syndr. 2018 Nov;12(6):1007-1011. doi: 10.1016/j.dsx.2018.06.015. Epub 2018 Jun 28.
Evidence from epidemiological studies suggests an important association between gout and the metabolic syndrome (MetS). However, to the best of our knowledge, prevalence of metabolic syndrome in gout has not been reported in sub-Saharan African (SSA) settings.
The aim of this study was to determine the prevalence and characteristics of MetS in gout in a SSA population.
After prior ethical clearance, we carried out a cross-sectional study involving gout patients in a referral hospital in Douala-Cameroon. Metabolic syndrome was defined using International Diabetes Foundation criteria. Associations between variables were assessed using logistic regression.p < 0.05 was considered significant.
On 174 gout patients (48.3% females) who consented to participate in the study, the median (IQR) age was 55.00 (14.25) years, and the median (IQR) duration of gout was 7.5 (10.0) years. Prevalence of metabolic syndrome was 54.6% (95% CI: 47.9%-62.8%). One hundred and forty-seven (84.5%) participants had central obesity, 62 (35.6%) raised triglycerides, 79 (45.4%) reduced HDL-C, 129 (74.1%) raised blood pressure, and 85 (48.9%) had raised fasting plasma glucose. On logistic regression analyses, gout patients with metabolic syndrome significantly had a higher body mass index (OR: 1.09, 95% CI: 1.02-1.17), and higher levels of serum uric acid (OR: 1.02, 95% CI: 1.01-1.04).
About 1 out of every 2 gout patients in this population have metabolic syndrome. These gout patients with metabolic syndrome significantly have a higher body mass index, and higher levels of serum uric acid. Cohort studies are required to clearly establish the direction of the relationship between gout and metabolic syndrome.
流行病学研究证据表明痛风与代谢综合征（MetS）之间存在重要关联。然而，据我们所知，撒哈拉以南非洲（SSA）地区痛风患者中代谢综合征的患病率尚未见报道。
本研究旨在确定SSA人群中痛风患者代谢综合征的患病率及特征。
在获得伦理批准后，我们在喀麦隆杜阿拉一家转诊医院对痛风患者进行了一项横断面研究。代谢综合征采用国际糖尿病联盟标准进行定义。使用逻辑回归评估变量之间的关联。p < 0.05被认为具有统计学意义。
174名同意参与研究的痛风患者（48.3%为女性），中位（四分位间距）年龄为55.00（14.25）岁，痛风的中位（四分位间距）病程为7.5（10.0）年。代谢综合征的患病率为54.6%（95%可信区间：47.9% - 62.8%）。147名（84.5%）参与者存在中心性肥胖，62名（35.6%）甘油三酯升高，79名（45.4%）高密度脂蛋白胆固醇降低，129名（74.1%）血压升高，85名（48.9%）空腹血糖升高。逻辑回归分析显示，患有代谢综合征的痛风患者体重指数显著更高（比值比：1.09，95%可信区间：1.02 - 1.17），血清尿酸水平也更高（比值比：1.02，95%可信区间：1.01 - 1.04）。
该人群中每2名痛风患者约有1名患有代谢综合征。这些患有代谢综合征的痛风患者体重指数显著更高，血清尿酸水平也更高。需要进行队列研究以明确痛风与代谢综合征之间关系的方向。
