The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Institute of Embryo-Fetal Original Adult Disease, Shanghai Key Laboratory for Reproductive Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Sci China Life Sci. 2019 Jan;62(1):112-118. doi: 10.1007/s11427-018-9322-6. Epub 2018 Jul 6.
To investigate the effect of basal hormone levels including follicle stimulating hormone (FSH) and estradiol (E) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E, even though they had normal FSH. Older women with higher FSH had a worse outcome of pregnancy, especially with increased E level. The results suggest that a combination of FSH, E and age could effectively predict the pregnancy outcome for women undergoing IVF-ET, and we should encourage infertile women with diminished ovarian reserve, especially young infertile women, to try the assisted reproduction as early as possible. After 40-yearold, the cost-benefit ratio should be considered according to the ovarian function.
为了研究基础激素水平（包括卵泡刺激素（FSH）和雌二醇（E））和年龄对体外受精和胚胎移植（IVF-ET）妇女妊娠结局的影响，我们设计了一项回顾性队列分析，并收集了 2014 年 1 月至 2017 年 4 月期间接受 IVF 的患者信息。我们发现，无论激素水平如何，年轻女性的妊娠结局都明显好于年龄较大的女性。基础 E 水平较高的年轻女性妊娠结局下降，尽管她们的 FSH 正常。FSH 较高的老年女性妊娠结局更差，尤其是 E 水平升高时。结果表明，FSH、E 和年龄的组合可有效预测接受 IVF-ET 的女性的妊娠结局，我们应鼓励卵巢储备功能下降的不孕女性，尤其是年轻不孕女性尽早尝试辅助生殖。40 岁以后，应根据卵巢功能考虑成本效益比。
