[使用类胰凝乳蛋白酶抑制剂阻断辛德毕斯病毒在感染小鼠体内的复制]
[Blocking of Sindbis virus replication in the body of infected mice using an inhibitor of chymotrypsin-like proteases].
作者信息
Zhirnov O P, Ovcharenko A V, Bukrinskaia A G
出版信息
Vopr Virusol. 1985 Jul-Aug;30(4):450-3.
PMID:2998094
Abstract
Parenteral administration of an inhibitor of chymotrypsin-like proteases (TPCK) to mice infected with alphavirus (Sindbis AR/339 strain) blocked virus replication in the brain and inhibited the development of viremia in the infected animals. The most likely mechanism of TPCK antiviral effect seems to consist in disturbance of proteolytic processing of viral proteins.
摘要
给感染甲病毒（辛德毕斯AR/339株）的小鼠经肠胃外途径注射一种类胰凝乳蛋白酶抑制剂（TPCK），可阻断病毒在脑中的复制，并抑制受感染动物体内病毒血症的发展。TPCK抗病毒作用最可能的机制似乎在于干扰病毒蛋白的蛋白水解加工过程。
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