NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway; Early Intervention in Psychosis Advisory Unit for South East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Norway.
NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Norway.
Compr Psychiatry. 2018 Aug;85:48-54. doi: 10.1016/j.comppsych.2018.06.004. Epub 2018 Jun 19.
Knowledge about self-rated disability over time in psychotic disorders is limited. How self-rated disability relates to clinician-rated global functioning, self-rated life satisfaction and symptomatology was investigated across the first year of treatment in early psychosis.
Participants with first treated episode of psychosis (n = 115) were investigated at baseline and 1-year follow-up. Self-rated Disability was measured with World Health Organization- Disability Assessment Schedule 2.0. Clinician-rated global functioning, self-rated life satisfaction, and symptomatology were measured with appropriate scales.
Average self-rated disability in first-treated episode of psychosis was high, corresponding with the 10% highest in a general population sample. However, 37% were not disabled at a clinically significant level after one year. Self-rated disability was highest in the two social domains (Getting along with people and Participation in society), but improved significantly from baseline to 1-year. At 1-year follow-up self-rated disability had significant weak to medium correlations with clinician-rated global functioning and positive symptoms, and mainly medium to strong correlations with life satisfaction and depressive symptoms. Yet only baseline depression significantly predicted disability after one year.
Self-rated disability in first treated episode of psychosis is high, but improves across the first year, indicating signs of early recovery. Moreover, self-rated disability is related, but distinct from clinician-rated global functioning and self-rated life satisfaction, suggesting that self-rated disability should also be assessed in order to more fully describe outcomes in first episode psychosis. The findings highlight the need for specialised treatment of depression and social disability in early psychosis.
关于精神障碍患者自评残疾随时间变化的知识有限。本研究旨在探讨首发精神病患者在治疗的第一年中,自评残疾与临床医生评定的总体功能、自评生活满意度和症状之间的关系。
本研究纳入了 115 名首发精神病患者,分别在基线和 1 年随访时进行评估。使用世界卫生组织残疾评定量表 2.0 评估自评残疾。使用适当的量表评估临床医生评定的总体功能、自评生活满意度和症状。
首发精神病患者的平均自评残疾程度较高,与一般人群样本中残疾程度最高的 10%相当。然而,一年后有 37%的患者没有达到临床显著残疾水平。自评残疾在两个社会领域(与人相处和参与社会)中最高,但从基线到 1 年随访时显著改善。在 1 年随访时,自评残疾与临床医生评定的总体功能和阳性症状呈弱至中度相关,与生活满意度和抑郁症状呈中至高相关。然而,只有基线时的抑郁症状在一年后显著预测残疾。
首发精神病患者的自评残疾程度较高,但在第一年中有所改善,表明有早期康复的迹象。此外,自评残疾与临床医生评定的总体功能和自评生活满意度相关,但又有所不同,这表明为了更全面地描述首发精神病患者的结局,也应评估自评残疾。这些发现强调了在早期精神病中专门治疗抑郁和社会残疾的必要性。