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膳食纤维用于治疗儿童单纯性、特发性、复发性腹痛的前瞻性、双盲、随机对照试验结果。

The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent, abdominal pain. Results in a prospective, double-blind, randomized, controlled trial.

作者信息

Feldman W, McGrath P, Hodgson C, Ritter H, Shipman R T

出版信息

Am J Dis Child. 1985 Dec;139(12):1216-8. doi: 10.1001/archpedi.1985.02140140050025.

Abstract

Recurrent abdominal pain (RAP) affects 10% to 18% of school-age children and is caused by obvious organic pathology in fewer than 10% of cases. Two recent studies do not support previous beliefs that most RAP is psychogenic. Studies have shown disorders of bowel motility in children with RAP similar to those of adult irritable bowel syndrome (IBS); controlled trials of additional dietary fiber in adult IBS have shown beneficial results. We did a randomized, double-blind, placebo-controlled study in 52 children with RAP and demonstrated a clinically and statistically significant decrease in pain attacks (at least 50% fewer) in almost twice as many children who were given additional fiber as placebo. Compliance was excellent in both groups and side effects were few. Although the cause of RAP is poorly understood, it is hypothesized that the beneficial effect of added fiber is due to its effect on shortening transit time, as in IBS.

摘要

复发性腹痛(RAP)影响10%至18%的学龄儿童,不到10%的病例由明显的器质性病变引起。最近的两项研究不支持先前大多数RAP是心因性的观点。研究表明,RAP患儿的肠道动力障碍与成人肠易激综合征(IBS)相似;成人IBS补充膳食纤维的对照试验已显示出有益效果。我们对52名RAP患儿进行了一项随机、双盲、安慰剂对照研究,结果表明,服用额外纤维的患儿疼痛发作次数在临床和统计学上均显著减少(至少减少50%),人数几乎是服用安慰剂患儿的两倍。两组的依从性都很好,副作用很少。虽然RAP的病因尚不清楚,但据推测,额外添加纤维的有益作用是由于其对缩短转运时间的影响,就像在IBS中一样。

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