Andaman and Nicobar Centre for Ocean Science and Technology, Earth System Sciences Organization-National Institute of Ocean Technology (ESSO-NIOT), Port Blair 744103, Andaman and Nicobar Islands, India.
Andaman and Nicobar Centre for Ocean Science and Technology, Earth System Sciences Organization-National Institute of Ocean Technology (ESSO-NIOT), Port Blair 744103, Andaman and Nicobar Islands, India.
Infect Genet Evol. 2018 Nov;65:1-5. doi: 10.1016/j.meegid.2018.07.008. Epub 2018 Jul 6.
Deep Sea sediment cores were collected from the surrounding of active volcanic Barren Island, Andaman & Nicobar Islands. A total of 24 halophilic eubacteria were isolated and identified based on their biochemical and 16S rDNA sequences. Three major classes (Gamma-Proteobacteria, Alpha-Proteobacteria and Bacilli) of bacteria were detected in the deep sea sediments of active volcanic Barren Island. Among those, 37% of isolates exhibited antimicrobial activity against all tested Gram positive and Gram negative clinical pathogens. 60% of isolates revealed the presence of either PKS or NRPS genes and 65% isolates disclosed medium to higher level of cytotoxicity in MB-231 breast cancer cell line. Majority of the isolates revealed excellent potential for bioprospecting of novel byproducts with industrial and pharmaceutical importance.
从安得拉邦和尼科巴群岛的活跃火山巴里安岛周围采集了深海沉积物岩芯。根据其生化和 16S rDNA 序列，共分离鉴定了 24 株嗜盐真细菌。在巴里安岛活跃火山的深海沉积物中检测到了三大类细菌（γ-变形菌、α-变形菌和芽孢杆菌）。其中，37%的分离物对所有测试的革兰氏阳性和革兰氏阴性临床病原体均表现出抗菌活性。60%的分离物显示出 PKS 或 NRPS 基因的存在，65%的分离物在 MB-231 乳腺癌细胞系中显示出中等至较高水平的细胞毒性。大多数分离物显示出具有工业和制药重要性的新型副产物的生物勘探的巨大潜力。
