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美洲印第安人线粒体DNA中的显著奠基者效应。

Dramatic founder effects in Amerindian mitochondrial DNAs.

作者信息

Wallace D C, Garrison K, Knowler W C

出版信息

Am J Phys Anthropol. 1985 Oct;68(2):149-55. doi: 10.1002/ajpa.1330680202.

DOI:10.1002/ajpa.1330680202
PMID:2998196
Abstract

Southwestern American Indian (Amerindian) mitochondrial DNAs (mtDNAs) were analyzed with restriction endonucleases and found to contain Asian restriction fragment length polymorphisms (RFLPs) but at frequencies very different from those found in Asia. One rare Asian HincII RFLP was found in 40% of the Amerindians. Several mtDNAs were discovered which have not yet been observed on other continents and different tribes were found to have distinctive mtDNAs. Since the mtDNA is inherited exclusively through the maternal lineage, these results suggest that Amerindian tribes were founded by small numbers of female lineages and that new mutations have been fixed in these lineages since their separation from Asia.

摘要

利用限制性内切酶对美国西南部印第安人(美洲印第安人)的线粒体DNA(mtDNA)进行了分析,发现其含有亚洲限制性片段长度多态性(RFLP),但频率与在亚洲发现的频率非常不同。在40%的美洲印第安人中发现了一种罕见的亚洲HincII RFLP。发现了几种在其他大陆尚未观察到的mtDNA,并且发现不同部落有独特的mtDNA。由于mtDNA仅通过母系遗传,这些结果表明美洲印第安部落是由少数母系血统建立的,并且自与亚洲分离以来,新的突变已在这些血统中固定下来。

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1
Dramatic founder effects in Amerindian mitochondrial DNAs.美洲印第安人线粒体DNA中的显著奠基者效应。
Am J Phys Anthropol. 1985 Oct;68(2):149-55. doi: 10.1002/ajpa.1330680202.
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American Indian prehistory as written in the mitochondrial DNA: a review.线粒体DNA所书写的美洲印第安人史前史:综述
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Genetic relationships between Amerindian populations of Argentina.阿根廷美洲印第安人群体之间的遗传关系。
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