Henry M L, Sommer B G, Ferguson R M
Am J Surg. 1985 Nov;150(5):533-6. doi: 10.1016/0002-9610(85)90431-3.
Recent reports have intimated that the use of antilymphocyte globulin in combination with azathioprine and steroids has ameliorated the beneficial affects of cyclosporine. We believe that even in the absence of significant statistical differences between patient survival rates and graft survival rates of cyclosporine-treated renal transplant patients compared with conventionally treated renal transplant patients, there are distinct advantages to cyclosporine use in renal transplantation. Twenty-three consecutive cadaveric renal transplant patients who received azathioprine, prednisone, and antilymphoblast globulin were compared with 23 cadaveric renal transplant patients who received cyclosporine and prednisone. Fewer statistically significant rejection episodes, multiple rejection episodes, and cytomegalovirus infections were demonstrated in those who received cyclosporine. Most notably, cyclosporine decreased the initial hospital stay, was associated with fewer readmissions, and therefore markedly reduced the initial cost of transplantation.
最近的报告暗示，抗淋巴细胞球蛋白与硫唑嘌呤和类固醇联合使用会减弱环孢素的有益效果。我们认为，即使与传统治疗的肾移植患者相比，环孢素治疗的肾移植患者的生存率和移植物存活率没有显著的统计学差异，但在肾移植中使用环孢素仍有明显优势。将连续23例接受硫唑嘌呤、泼尼松和抗淋巴细胞球蛋白的尸体肾移植患者与23例接受环孢素和泼尼松的尸体肾移植患者进行比较。接受环孢素的患者出现的具有统计学意义的排斥反应、多次排斥反应和巨细胞病毒感染较少。最值得注意的是，环孢素缩短了初次住院时间，再入院次数较少，因此显著降低了初次移植成本。
