Mathew Roshin C, Gottbrecht Matthew, Salerno Michael
Department of Medicine, University of Virginia Health System, University of Virginia, 131 Hospital Drive, Suite 1031, Charlottesville, VA 22904, USA.
Department of Medicine, University of Virginia Health System, University of Virginia, 131 Hospital Drive, Suite 1031, Charlottesville, VA 22904, USA; Department of Radiology and Medical Imaging, The Cardiovascular Imaging Center, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA 22908, USA; Department of Biomedical Engineering, University of Virginia Health System, 415 Lane Road, Room 2010, Charlottesville, VA 22908, USA; Cardiovascular Division, University of Virginia Health System, 1215 Lee Street, PO Box 800158, Charlottesville, VA 22908, USA.
Interv Cardiol Clin. 2018 Jul;7(3):345-354. doi: 10.1016/j.iccl.2018.03.008. Epub 2018 Jun 29.
Computed tomography angiography (CTA) has played a significant role in evaluation of coronary artery disease in the last decade and has demonstrated high sensitivity and negative predictive values. However, the positive predictive value as compared with invasive fractional flow reserve (FFR) is limited. CT-FFR has emerged as a disruptive noninvasive technology with higher specificity and diagnostic accuracy for detection of hemodynamically significant coronary lesions as compared with invasive FFR than conventional coronary CTA. CT-FFR has been shown to be cost-effective as a gate-keeper to invasive coronary angiography and has the potential to limit unnecessary invasive angiography studies.
在过去十年中，计算机断层扫描血管造影（CTA）在冠状动脉疾病评估中发挥了重要作用，并显示出高敏感性和阴性预测值。然而，与有创血流储备分数（FFR）相比，其阳性预测值有限。与传统冠状动脉CTA相比，CT-FFR作为一种突破性的非侵入性技术，在检测具有血流动力学意义的冠状动脉病变方面具有更高的特异性和诊断准确性，与有创FFR相比也是如此。CT-FFR已被证明作为有创冠状动脉造影的把关手段具有成本效益，并有潜力限制不必要的有创血管造影检查。
