Guangzhou Institute of Cardiovascular Diseases, The Second Affiliated Hospital; Key Laboratory of Cardiovascular Diseases, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK.
Trends Endocrinol Metab. 2018 Aug;29(8):571-580. doi: 10.1016/j.tem.2018.06.001. Epub 2018 Jul 5.
The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.
绝经后女性骨质疏松症和心血管疾病的风险显著增加。直到最近，其潜在机制主要归因于绝经后雌激素水平下降。然而，在绝经过渡期间，卵泡刺激素 (FSH) 水平急剧上升，并在多年内维持在较高水平。FSH 受体已在各种性腺外部位检测到，包括破骨细胞和成内皮细胞。最近的研究进展表明，FSH 可能导致绝经后骨质疏松症和心血管疾病。在这里，我们回顾了 FSH 如何通过女性绝经过渡导致骨质疏松症和心血管疾病的风险的关键作用。深入了解 FSH 促进骨质疏松症和心血管疾病的确切机制可能为改善绝经后女性的健康寿命提供新的机会。
