Lin Yunting, Song Endi, Jin Han, Jin Yong
Department of Surgical Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China.
Department of Internal Medicine, Ningbo Yinzhou No.2 Hospital, Ningbo, Zhejiang, China.
Endocr Connect. 2024 Aug 19;13(9). doi: 10.1530/EC-24-0190. Print 2024 Sep 1.
Reproductive hormones may be a risk factor for cardiovascular disease (CVD), but their influence is often underestimated. Obesity can exacerbate the progression of CVD. Arterial stiffness (AS) is correlated with the risk of CVD. Brachial-ankle pulse wave velocity (baPWV) has served as a practical tool for assessing AS with broad clinical applications. This study aimed to investigate the association between reproductive hormones and baPWV in obese male and female subjects.
A retrospective case-control design was designed. AS was assessed using baPWV, with a baPWV ≥ 1400 cm/s indicating increased AS. Between September 2018 and October 2022, 241 obese subjects with increased AS were recruited from Ningbo Yinzhou No. 2 Hospital. The control group consisted of 241 obese subjects without increased AS. A 1:1 propensity score matching was performed to correct potential confounders by age and sex. We additionally performed a sex-based sub-analysis.
Correlation analysis demonstrated that luteinizing hormone (LH) (r = 0.214, P = 0.001) and follicle-stimulating hormone (FSH) (r = 0.328, P < 0.001) were positively correlated with baPWV in obese male subjects. In the multivariate conditional logistic regression analysis, FSH (OR = 1.407, 95% CI = 1.040-1.902, P = 0.027) rather than LH (OR = 1.210, 95% CI = 0.908-1.612, P = 0.194) was independently and positively associated with increased AS in obese male subjects. However, there was no significant correlation between reproductive hormones and baPWV in women.
Our study identified FSH as a potential risk factor for arteriosclerosis in obese male subjects. This provides a novel and intriguing perspective on the pathogenesis of CVD in obese subjects.
生殖激素可能是心血管疾病（CVD）的一个危险因素，但其影响常常被低估。肥胖会加剧CVD的进展。动脉僵硬度（AS）与CVD风险相关。肱踝脉搏波速度（baPWV）已成为评估AS的实用工具，具有广泛的临床应用。本研究旨在调查肥胖男性和女性受试者中生殖激素与baPWV之间的关联。
采用回顾性病例对照设计。使用baPWV评估AS，baPWV≥1400 cm/s表明AS增加。在2018年9月至2022年10月期间，从宁波市鄞州第二医院招募了241名AS增加的肥胖受试者。对照组由241名AS未增加的肥胖受试者组成。进行1:1倾向评分匹配以校正年龄和性别的潜在混杂因素。我们还进行了基于性别的亚组分析。
相关性分析表明，在肥胖男性受试者中，黄体生成素（LH）（r = 0.214，P = 0.001）和卵泡刺激素（FSH）（r = 0.328，P < 0.001）与baPWV呈正相关。在多变量条件逻辑回归分析中，FSH（OR = 1.407，95%CI = 1.040 - 1.902，P = 0.027）而非LH（OR = 1.210，95%CI = 0.908 - 1.612，P = 0.194）与肥胖男性受试者AS增加独立且呈正相关。然而，女性受试者中生殖激素与baPWV之间无显著相关性。
我们的研究确定FSH是肥胖男性受试者动脉粥样硬化的潜在危险因素。这为肥胖受试者CVD的发病机制提供了一个新颖而有趣的视角。
