Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec G1V 0A6, Canada; Functional Genomics Laboratory, CREMI, Québec Genome Center, CHUL-CHU de Québec Research Center, Québec, Québec G1V 4G2, Canada.
Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec G1V 0A6, Canada; Functional Genomics Laboratory, CREMI, Québec Genome Center, CHUL-CHU de Québec Research Center, Québec, Québec G1V 4G2, Canada.
Cytokine. 2018 Dec;112:132-136. doi: 10.1016/j.cyto.2018.06.034. Epub 2018 Jul 6.
Interleukin 6 (IL-6) is a cytokine that is involved in divers immune responses and implicated in a number of diseases. However, this cytokine has other non-immune functions. Within this review, we highlight selected effects on metabolic pathways, which are mediated, controlled or modified by the IL-6. Importantly, putting spotlight on such concepts could allow us to classify IL-6 among the metabolic hormones and further study it to both deepen our knowledge on disorders involving metabolic or energy imbalances such as obesity and develop novel therapeutic strategies. Furthermore, potential explanations related to IL-6 roles in both physiology and pathology as well as relevant implications and applications on both research and therapeutic fields are also pointed as consequences of the involvement of IL-6 in the energy and metabolic homeostasis via its "endocrine" roles.
白细胞介素 6（IL-6）是一种细胞因子，参与多种免疫反应，并与许多疾病有关。然而，这种细胞因子还有其他非免疫功能。在这篇综述中，我们强调了其对代谢途径的一些选定影响，这些影响是由 IL-6 介导、控制或修饰的。重要的是，关注这些概念可以使我们将 IL-6 归类为代谢激素，并进一步研究它，以加深我们对涉及代谢或能量失衡的疾病（如肥胖症）的认识，并开发新的治疗策略。此外，还指出了与 IL-6 在生理和病理中的作用相关的潜在解释，以及 IL-6 通过其“内分泌”作用参与能量和代谢稳态的相关意义和应用，这也是 IL-6 参与的结果。
