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成年烧伤患者的感染并发症及分离出的微生物的抗菌耐药模式。

Infectious complications in adult burn patients and antimicrobial resistance pattern of microorganisms isolated.

作者信息

Zampar E F, Anami E H T, Kerbauy G, Queiroz L F T, Carrilho C M D M, Cardoso L T Q, Grion C M C

机构信息

Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

出版信息

Ann Burns Fire Disasters. 2017 Dec 31;30(4):281-285.

Abstract

The objective of this study was to analyze the incidence of hospital acquired infections (HAIs) in burn patients, and to determine the principle infection sites and the sensitivity profile of the microorganisms to antimicrobials. This is a retrospective cohort study, conducted in a specialized centre for the treatment of burns from January 2009 to December 2013. The sample consisted of 404 patients, divided into two groups: the first group comprised 142 patients without infection, and the second group was made up of 262 patients who had acquired HAIs. There was a predominance of males in both groups. Mean age of the patients without infection was 37 years (SD 14.89), and 38 years (SD 15.78) for the patients with HAIs. Of the 523 infections observed in this study, pneumonia was the most frequent with 216 (41%) cases, followed by urinary tract infections with 137 (26%) episodes. The pathogens identified were Acinetobacter baumannii (93, 40%), Pseudomonas aeruginosa (50, 21%) and Klebsiella (pneumoniae/oxytoca) (23, 10%) and were resistant to most common antimicrobials. In the study population, no pathogens resistant to vancomycin were found. The present study describes high rates of infection in burn victims. Pneumonia was the most frequent site of infection, followed by urinary tract infections caused respectively by non-fermenting bacteria with a high frequency of antimicrobial resistance.

摘要

本研究的目的是分析烧伤患者医院获得性感染(HAIs)的发生率,确定主要感染部位以及微生物对抗菌药物的敏感性。这是一项回顾性队列研究,于2009年1月至2013年12月在一家烧伤治疗专科医院进行。样本包括404名患者,分为两组:第一组由142名未感染患者组成,第二组由262名发生HAIs的患者组成。两组中男性均占多数。未感染患者的平均年龄为37岁(标准差14.89),发生HAIs的患者平均年龄为38岁(标准差15.78)。在本研究观察到的523例感染中,肺炎最为常见,有216例(41%),其次是尿路感染,有137例(26%)。鉴定出的病原体为鲍曼不动杆菌(93例,40%)、铜绿假单胞菌(50例,21%)和克雷伯菌(肺炎克雷伯菌/产酸克雷伯菌)(23例,10%),它们对大多数常用抗菌药物耐药。在研究人群中,未发现对万古霉素耐药的病原体。本研究描述了烧伤患者的高感染率。肺炎是最常见的感染部位,其次是尿路感染,分别由具有高耐药频率的非发酵菌引起。

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