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本文引用的文献

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Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder.哌甲酯对韩国注意缺陷多动障碍儿童身体指数和体能的影响。
Hum Psychopharmacol. 2016 Mar;31(2):76-82. doi: 10.1002/hup.2514. Epub 2016 Jan 12.
2
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).用于治疗儿童和青少年注意力缺陷多动障碍（ADHD）的哌甲酯。
Cochrane Database Syst Rev. 2015 Nov 25;2015(11):CD009885. doi: 10.1002/14651858.CD009885.pub2.
3
Differential therapeutic effects of 12-week treatment of atomoxetine and methylphenidate on drug-naïve children with attention deficit/hyperactivity disorder: A counting Stroop functional MRI study.12周托莫西汀和哌甲酯治疗对未用过药物的注意缺陷/多动障碍儿童的差异治疗效果：一项计数斯特鲁普功能磁共振成像研究
Eur Neuropsychopharmacol. 2015 Dec;25(12):2300-10. doi: 10.1016/j.euroneuro.2015.08.024. Epub 2015 Sep 8.
4
Sudden hearing loss associated with methylphenidate therapy.与哌醋甲酯治疗相关的突发性听力损失。
Eur Arch Otorhinolaryngol. 2014 Jan;271(1):199-201. doi: 10.1007/s00405-013-2763-y. Epub 2013 Oct 19.
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Confounding diagnoses in the neurodevelopmental disabilities population: a child with hearing loss, absence epilepsy, and attention-deficit hyperactivity disorder (ADHD).
J Child Neurol. 2013 May;28(5):645-7. doi: 10.1177/0883073812447980. Epub 2012 Jul 2.
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The occurrence of adverse drug reactions reported for attention deficit hyperactivity disorder (ADHD) medications in the pediatric population: a qualitative review of empirical studies.在儿科人群中报告的注意力缺陷多动障碍（ADHD）药物不良反应的发生情况：对经验研究的定性综述。
Neuropsychiatr Dis Treat. 2011;7:729-44. doi: 10.2147/NDT.S26403. Epub 2011 Dec 16.
7
Sleep habits, parasomnias and associated behaviors in school children with attention deficit hyperactivity disorder (ADHD).患有注意力缺陷多动障碍（ADHD）的学童的睡眠习惯、异态睡眠及相关行为。
Turk J Pediatr. 2011 Jul-Aug;53(4):397-403.
8
Clinical features of functional hearing loss with inattention problem in Japanese children.日本儿童功能性听力损失伴注意力不集中问题的临床特征
Int J Pediatr Otorhinolaryngol. 2011 Nov;75(11):1431-5. doi: 10.1016/j.ijporl.2011.08.009. Epub 2011 Sep 8.
9
Methylphenidate normalizes fronto-striatal underactivation during interference inhibition in medication-naïve boys with attention-deficit hyperactivity disorder.哌醋甲酯可使未经药物治疗的注意缺陷多动障碍男孩在抑制干扰过程中额纹状体功能低下得到矫正。
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10
Parental reporting of adverse drug reactions associated with attention-deficit hyperactivity disorder (ADHD) medications in children attending specialist paediatric clinics in the UK.家长报告在英国专科儿科诊所就诊的儿童使用注意力缺陷多动障碍（ADHD）药物相关的不良反应。
Drug Saf. 2011 Mar 1;34(3):211-9. doi: 10.2165/11586050-000000000-00000.

哌甲酯对注意力缺陷多动障碍儿童听力的影响。

The Effect of Methylphenidate on the Hearing of Children with Attention Deficit Hyperactivity Disorder.

作者信息

İsmi Onur, Yildirim Veli, Vayisoglu Yusuf, Togrul Anis, Toros Fevziye, Unal Murat

机构信息

Department of Otorhinolaryngology, Mersin Üniversitesi, Mersin, Turkey.

Department of Child and Adolescent Psychiatry Mersin Üniversitesi, Mersin, Turkey.

出版信息

Int Arch Otorhinolaryngol. 2018 Jul;22(3):220-224. doi: 10.1055/s-0037-1605367. Epub 2017 Aug 7.

DOI:10.1055/s-0037-1605367
PMID:29983758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6033592/
Abstract

There has been a sudden idiopathic hearing loss case presented after methylphenidate treatment in a child with attention deficit hyperactivity disorder (ADHD).  This study was performed to reveal the probable ototoxic side effects of methylphenidate use in patients with ADHD.  Thirty pediatric patients with ADHD were included in the study. Pure tone audiometry, speech discrimination scores, waves I, III, V absolute latencies and waves I-III, I-V, III-V interpeak latencies at the 80 dB nHL intensity after click stimulus auditory brainstem response (ABR) results were compared before and 3 months after methylphenidate treatment.  There were no statistically significant difference between pretreatment and posttreatment pure tone and speech audiometry findings and ABR results (p > 0.05 for all parameters).  Methylphenidate can be regarded as a safe drug regarding ototoxic side effects. Additional studies with a larger sample size and longer follow-up may be needed.

摘要

一名患有注意力缺陷多动障碍（ADHD）的儿童在使用哌甲酯治疗后出现了突发性特发性听力损失病例。本研究旨在揭示哌甲酯在ADHD患者中可能存在的耳毒性副作用。30名患有ADHD的儿科患者被纳入研究。比较了哌甲酯治疗前和治疗3个月后在80 dB nHL强度下短声刺激听性脑干反应（ABR）结果中的纯音听力测定、言语辨别分数、波I、III、V绝对潜伏期以及波I-III、I-V、III-V峰间潜伏期。治疗前和治疗后的纯音和言语听力测定结果以及ABR结果之间无统计学显著差异（所有参数p>0.05）。就耳毒性副作用而言，哌甲酯可被视为一种安全的药物。可能需要进行更大样本量和更长随访时间的进一步研究。