Claesdotter-Knutsson Emma, Källstrand Johan, Niklasson Katalin, Andersson Mitchell, Lindvall Magnus
Psychiatry, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Independent Researcher.
J Public Health Res. 2023 Oct 11;12(4):22799036231204319. doi: 10.1177/22799036231204319. eCollection 2023 Oct.
Attention-deficit hyperactivity disorder (ADHD), characterized by periods of inattention, overactivity, and impulsiveness, is the most prevalent neurodevelopmental disorder among children. Auditory Brainstem Response (ABR) is a technique in which clickshaped sounds elicit potentials that are recorded from electrodes placed on a patient's skull. Extant research indicates that ABR is frequently affected in neurodevelopmental disorders such as ADHD. Methylphenidate (MPH), a psychostimulant, is often prescribed to children with ADHD as a first-line pharmacological treatment. The aim of this study was to explore the effects of Methylphenidate treatment on previously observed amplitude alterations in the ABR of patients with ADHD.
We recruited 32 drug-naïve children and adolescents (19 males and 13 females; mean age 11 years) diagnosed with ADHD and 35 health controls (15 males and 20 females; mean age 12 years). The ADHD group was treated with Methylphenidate, and ABR was recorded before treatment and at a steady state of medical treatment.
Medicated ADHD patients exhibited increased activity in the right side ABR in Wave VI.
A significant increase in activity was found in a part of the ABR thought to correspond to the thalamic area in medicated ADHD patients compared to the same area of non-medicated ADHD patients. The results add to the growing body of research suggesting that specific ABR peaks correlate to certain psychiatric symptoms.
注意力缺陷多动障碍（ADHD）的特征是注意力不集中、多动和冲动，是儿童中最常见的神经发育障碍。听觉脑干反应（ABR）是一种技术，其中点击状声音引发从放置在患者颅骨上的电极记录的电位。现有研究表明，ABR在诸如ADHD等神经发育障碍中经常受到影响。哌甲酯（MPH），一种精神兴奋剂，常被开给患有ADHD的儿童作为一线药物治疗。本研究的目的是探讨哌甲酯治疗对先前观察到的ADHD患者ABR振幅改变的影响。
我们招募了32名未服用过药物的被诊断患有ADHD的儿童和青少年（19名男性和13名女性；平均年龄11岁）以及35名健康对照者（15名男性和20名女性；平均年龄12岁）。ADHD组接受哌甲酯治疗，并在治疗前和药物治疗稳定状态下记录ABR。
接受药物治疗的ADHD患者在波VI的右侧ABR中表现出活动增加。
与未接受药物治疗的ADHD患者的同一区域相比，在接受药物治疗的ADHD患者中，发现ABR中被认为与丘脑区域相对应的部分活动显著增加。这些结果进一步丰富了越来越多的研究，表明特定的ABR峰值与某些精神症状相关。
