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人类中性粒细胞呼吸爆发的激活仅在17摄氏度以上的温度下发生:激活需要膜融合的证据。

The activation of the human neutrophil respiratory burst occurs only at temperatures above 17 degrees C: evidence that activation requires membrane fusion.

作者信息

Manara F S, Schneider D L

出版信息

Biochem Biophys Res Commun. 1985 Oct 30;132(2):696-701. doi: 10.1016/0006-291x(85)91188-x.

DOI:10.1016/0006-291x(85)91188-x
PMID:2998379
Abstract

By considering the effects of temperature on the respiratory burst activity of human neutrophils stimulated by phorbol myristate acetate, we have found that activation only occurs at 17 degrees C and above. Between 20 and 30 degrees C, the rates of oxygen consumption rose dramatically in correspondence with cellular release of gelatinase and lactoferrin. Inasmuch as these mark tertiary and specific granules, respectively, a necessity for membrane fusion of one or both granules with the plasma membrane during triggering of the respiratory burst is very probable.

摘要

通过研究温度对佛波酯刺激的人中性粒细胞呼吸爆发活性的影响,我们发现激活仅在17摄氏度及以上温度时发生。在20到30摄氏度之间,耗氧率随着明胶酶和乳铁蛋白的细胞释放而急剧上升。由于这些分别标志着三级颗粒和特异性颗粒,因此在呼吸爆发触发过程中,一种或两种颗粒与质膜发生膜融合是很有可能的。

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1
The activation of the human neutrophil respiratory burst occurs only at temperatures above 17 degrees C: evidence that activation requires membrane fusion.人类中性粒细胞呼吸爆发的激活仅在17摄氏度以上的温度下发生:激活需要膜融合的证据。
Biochem Biophys Res Commun. 1985 Oct 30;132(2):696-701. doi: 10.1016/0006-291x(85)91188-x.
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Intracellular organelle motility and membrane fusion processes in human neutrophils upon cell activation.
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Cytochrome b co-fractionates with gelatinase-containing granules in human neutrophils.细胞色素b与人中性粒细胞中含明胶酶的颗粒共分离。
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Release of gelatinase from a novel secretory compartment of human neutrophils.人中性粒细胞新型分泌区室中明胶酶的释放。
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Role of degranulation in activation of the respiratory burst in human neutrophils.脱颗粒在人中性粒细胞呼吸爆发激活中的作用。
J Leukoc Biol. 1991 May;49(5):489-98. doi: 10.1002/jlb.49.5.489.
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Human neutrophil gelatinase is a component of specific granules.人中性粒细胞明胶酶是特异性颗粒的一个组成部分。
J Clin Invest. 1989 Nov;84(5):1395-402. doi: 10.1172/JCI114312.
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Annexin 3 is associated with cytoplasmic granules in neutrophils and monocytes and translocates to the plasma membrane in activated cells.膜联蛋白3与中性粒细胞和单核细胞的细胞质颗粒相关,并在活化细胞中转位至质膜。
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Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.高血压患者中性粒细胞颗粒与细胞膜的快速融合可能会增加血管损伤。
Am J Hypertens. 2001 Sep;14(9 Pt 1):927-33. doi: 10.1016/s0895-7061(01)02136-7.

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