Haliti Arsim, Mustafa Lirim, Bexheti Sadi, Islami Drita, Bozalija Adnan, Shabani Ragip, Islami Hilmi
Department of Pharmacy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Institution KFLM, Agim Ramadani, Prishtina, Kosovo.
Open Access Maced J Med Sci. 2018 Jun 13;6(6):992-996. doi: 10.3889/oamjms.2018.244. eCollection 2018 Jun 20.
Here we studied the role of meconium in the respiratory system on live and exited newborns (weight 250-3000 g). Throughout this study is followed the response of tracheal rings in acetylcholine and histamine in different molar concentrations (10, 10, 10, 10 mol/dm).
To study the smooth tracheal musculature we used 23 tracheal preparations obtained from the newborns exited from meconium aspiration.
Based on the functional analysis of the tracheal specimen we have concluded that the meconium aspiration did not change the smooth musculature response on acetylcholine and histamine when compared to control group, exited from lung inflammatory processes (e.g., pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage), where tracheal smooth musculature response is significant (P for other causes is not significant (P > 0.01).
The conclusions suggest that meconium did not potentiate the constrictor action of acetylcholine and histamine in the tracheobronchial system and did not cause modulation of bronchomotor tonus in case of his aspiration. Meconium causes mild relaxation of smooth tracheal musculature with a mechanism which is not mediated by cyclooxygenase products, from tracheal epithelium or proteins. Also, direct activity in the smooth musculature of several tested acids seems to have no significant impact in increasing the tonus of respiratory airway of smooth tracheal musculature.
在此我们研究了胎粪在体重250 - 3000克的活产及已出生新生儿呼吸系统中的作用。在整个研究过程中，观察了不同摩尔浓度（10⁻⁴、10⁻⁵、10⁻⁶、10⁻⁷摩尔/立方分米）的乙酰胆碱和组胺作用下气管环的反应。
为研究气管平滑肌组织，我们使用了23份取自因胎粪吸入而出生的新生儿的气管标本。
基于对气管标本的功能分析，我们得出结论，与因肺部炎症过程（如肺炎、支气管肺炎、肺不张、脑出血）而出生的对照组相比，胎粪吸入并未改变气管平滑肌对乙酰胆碱和组胺的反应，在对照组中气管平滑肌反应显著（其他原因导致的P值不显著（P > 0.01）。
这些结论表明，胎粪不会增强乙酰胆碱和组胺在气管支气管系统中的收缩作用，在其吸入情况下也不会引起支气管运动张力的调节。胎粪会使气管平滑肌轻度松弛，其机制并非由气管上皮或蛋白质的环氧化酶产物介导。此外，几种测试酸在平滑肌中的直接活性似乎对增加气管平滑肌呼吸道张力没有显著影响。
