缺氧对新生儿呼吸窘迫综合征（DRS）时支气管对支气管收缩物质反应的影响。
Influence of hypoxia in bronchial response to bronchoconstrictor substances at newborn with distress respiratory syndrome (DRS).
作者信息
Bozalija Adnan, Islami Pëllumb, Gashi Njazi, Maloku Halit, Shabani Ragip, Bexheti Sadi, Islami Hilmi
机构信息
Department of Pharmacy, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
Smartmed, St. Rexhep Krasniqi, EXDC, Prishtina, Kosova.
出版信息
Med Arch. 2013;67(5):357-60. doi: 10.5455/medarh.2013.67.357-360.
OBJECTIVE
In this work, role of hypoxia in respiratory system on live and exited newborns weight 250-3000g.) which have died due to different reasons is studied.
METHODS
Response of tracheal rings in acetylcholine and histamine in different molar concentrations (10(-4), 10(-3), 10(-2), 10(-1) mol/dm3) was monitored. Study of the tracheal smooth musculature (TSM) tonus was performed in 12 tracheal preparations obtained from the newborns exited due to different reasons.
RESULTS
Based on the functional analysis of the isolated tracheal preparations, we have concluded that the cases born with lung atelectasis have caused significant response ofTSM to Acetylcholine and Histamine (p > 0.01). In cases of control group, which has exited due to different reasons from lung inflammatory processes (e.g.: pneumonia, bronchopneumonia, cerebral hemorrhage), Acetylcholine and Histamine have also caused significant constriction of tracheal smooth musculature.
CONCLUSION
Results suggest that exited cases with lung atelectasis (hypoxemia) and cases of lung inflammatory processes have significant constrictor action to Acetylcholine and Histamine in tracheobronchial system.
目的
本研究旨在探讨呼吸系统中的缺氧对体重250 - 3000克、因不同原因死亡的活产及死产新生儿的影响。
方法
监测不同摩尔浓度（10⁻⁴、10⁻³、10⁻²、10⁻¹mol/dm³）的乙酰胆碱和组胺对气管环的反应。对12份因不同原因死亡的新生儿气管标本进行气管平滑肌（TSM）张力研究。
结果
基于对分离气管标本的功能分析，我们得出结论，出生时伴有肺不张的病例，其TSM对乙酰胆碱和组胺有显著反应（p>0.01）。在因肺部炎症过程（如肺炎、支气管肺炎、脑出血）等不同原因死亡的对照组病例中，乙酰胆碱和组胺也引起了气管平滑肌的显著收缩。
结论
结果表明，伴有肺不张（低氧血症）的死亡病例和肺部炎症病例对气管支气管系统中的乙酰胆碱和组胺有显著的收缩作用。
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