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雌性大白鼠吸入咸海粉尘 - 盐气溶胶中毒状态下卵巢的形态学

Morphology of the Ovaries in Condition of Inhalation Intoxication with Dust-Saline Aerosols of the Aral Sea in Female White Rats.

作者信息

Turdybekova Yasminur G, Kopobayeva Irina L, Kultanov Berikbay Zh, Yesimova Roza Zh, Fedotovskikh Galina V

机构信息

Departments of Obstetrics and Gynecology, Molecular Biology and Medical Genetics, Histology, Karaganda State Medical University of the Ministry of Health of the Republic of Kazakhstan, 100008, Karaganda, Kazakhstan.

National Scientific Medical Center, Pathologicoanatomic Department, Astana, Kazakhstan.

出版信息

Open Access Maced J Med Sci. 2018 Jun 16;6(6):997-1002. doi: 10.3889/oamjms.2018.240. eCollection 2018 Jun 20.

DOI:10.3889/oamjms.2018.240
PMID:29983791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6026430/
Abstract

BACKGROUND

After some clinical studies of the reproductive health of the female population of the Aral Sea region, we concluded that it is necessary to confirm by experiment the theory of the direct influence of dust-saline aerosols of the Aral Sea on the reproductive system of female individuals.

AIM

The purpose of this work is to study the effect of dust-saline aerosols of the Aral Sea on the folliculogenesis process in rats at inhalation intoxication.

METHODS

Inhalation in rats was carried out for 30 days for 4 hours a day for 5 days a week in special inoculating cylindrical chambers with the extra-chamber placement of animals in individual boxes and dynamic aerosol delivery. Morphological changes were assessed using electron microscopy.

RESULTS

Ultrastructural changes in the ovaries of the experimental study group were characterised by the pathology of all structures of the cortical substance of the organ. The accumulation of lutein pigment, the utilisation of lipid inclusions and the destruction of the complete cell reflected the pathology of estrogen production-an important factor in the postovulatory phase of the ovarian cycle.

CONCLUSIONS

Taking into account the proven effect of dust-saline aerosols on the production of estrogen, the violation of the postovulatory phase of the ovarian cycle, we trace the mechanism of folliculogenesis disturbance. This confirms the data of our previous studies on primary and secondary infertility in women living in the Aral Sea region and the necessity of creation and development of preventive measures for the inhabitants of the region.

摘要

背景

在对咸海地区女性人群的生殖健康进行了一些临床研究之后，我们得出结论，有必要通过实验来证实咸海的沙尘 - 盐气溶胶对女性个体生殖系统的直接影响理论。

目的

这项工作的目的是研究咸海的沙尘 - 盐气溶胶对吸入性中毒大鼠卵泡发生过程的影响。

方法

在特殊的接种圆柱形舱中，每周5天，每天4小时，对大鼠进行30天的吸入实验，动物置于舱外的单独盒子中，并进行动态气溶胶输送。使用电子显微镜评估形态学变化。

结果

实验研究组大鼠卵巢的超微结构变化表现为器官皮质物质所有结构的病变。叶黄素色素的积累、脂质包涵体的利用和完整细胞的破坏反映了雌激素产生的病理变化——这是卵巢周期排卵后阶段的一个重要因素。

结论

考虑到沙尘 - 盐气溶胶对雌激素产生的已证实影响以及卵巢周期排卵后阶段的紊乱，我们追踪卵泡发生紊乱的机制。这证实了我们之前关于咸海地区女性原发性和继发性不孕的研究数据，以及为该地区居民制定和开展预防措施的必要性。

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本文引用的文献

1
Comparative Assessment of Women's Reproductive Health in the Areas Bordering With the Aral Sea Region.咸海地区周边区域妇女生殖健康的比较评估
Open Access Maced J Med Sci. 2017 Apr 8;5(2):261-265. doi: 10.3889/oamjms.2017.052. eCollection 2017 Apr 15.
2
The Health Status of the Reproductive System in Women Living In the Aral Sea Region.咸海地区女性生殖系统的健康状况
Open Access Maced J Med Sci. 2015 Sep 15;3(3):474-7. doi: 10.3889/oamjms.2015.078. Epub 2015 Jun 23.