Miller A K, Kong Y L, Stapley E O
Chemotherapy. 1977;23 Suppl 1:75-81. doi: 10.1159/000222029.
Haemophilus influenzae is an important pathogen in respiratory infections in children and often is implicated in otitis media. It is sensitive in vitro to a number of antibiotics, some of which are used clinically for the treatment of such infections. We have checked the in vitro sensitivity of a type b strain of H. influenzae. When tested in Levinthal's broth prepared with laked rabbit blood, the culture was most sensitive to tetracycline, ampicillin and penicillin and was somewhat less sensitive to cephalothin, fosfomycin, cephaloridine, and chloramphenicol. However, when this same strain was used to infect mice, fosfomycin was more active than ampicillin, tetracycline, chloramphenicol, penicillin or the cephalosporins.
流感嗜血杆菌是儿童呼吸道感染中的一种重要病原体，常与中耳炎有关。它在体外对多种抗生素敏感，其中一些在临床上用于治疗此类感染。我们检测了一株b型流感嗜血杆菌的体外敏感性。在用溶血兔血制备的列文索尔肉汤中进行测试时，该培养物对四环素、氨苄西林和青霉素最敏感，对头孢噻吩、磷霉素、头孢匹林和氯霉素的敏感性稍低。然而，当用同一菌株感染小鼠时，磷霉素比氨苄西林、四环素、氯霉素、青霉素或头孢菌素更具活性。
