流感嗜血杆菌对抗生素的敏感性。
Sensitivity of Haemophilus influenzae to antibiotics.
作者信息
Williams J D, Andrews J
出版信息
Br Med J. 1974 Jan 26;1(5899):134-7. doi: 10.1136/bmj.1.5899.134.
Abstract
The use of many different antibiotics to treat chest infection has led us to test the sensitivity of 68 strains of Haemophilus influenzae to 15 different compounds. These included established compounds such as ampicillin and tetracycline and newer agents such as cephalosporins and clindamycin. The minimum inhibitory concentrations of the compounds for H. influenzae were then compared with blood levels attained after the usual dose regimens. There has been a significant increase in tetracycline resistance in the last few years, but all strains were sensitive to ampicillin, chloramphenicol, sulphamethoxazole, and trimethoprim, Several antibiotics were found to be microbiologically unsuitable for treating H. influenzae infections.
摘要
使用多种不同抗生素治疗胸部感染促使我们检测68株流感嗜血杆菌对15种不同化合物的敏感性。这些化合物包括已有的如氨苄西林和四环素，以及较新的药物如头孢菌素和克林霉素。然后将这些化合物对流感嗜血杆菌的最低抑菌浓度与常规给药方案后达到的血药浓度进行比较。在过去几年中，四环素耐药性显著增加，但所有菌株对氨苄西林、氯霉素、磺胺甲恶唑和甲氧苄啶敏感。发现几种抗生素在微生物学上不适用于治疗流感嗜血杆菌感染。
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本文引用的文献
1
"Penbritin": An Oral Penicillin with Broad-spectrum Activity.“青霉素V钾片”：一种具有广谱活性的口服青霉素。
Br Med J. 1961 Jul 22;2(5246):200-6. doi: 10.1136/bmj.2.5246.200.
2
COMPARISON OF THE BLOOD LEVELS OBTAINED AFTER SINGLE AND MULTIPLE DOSES OF ERYTHROMYCIN ESTOLATE AND ERYTHROMYCIN STEARATE.单次及多次服用依托红霉素和硬脂酸红霉素后血药浓度的比较。
Am J Med Sci. 1964 Jan;247:69-74. doi: 10.1097/00000441-196401000-00010.
3
Treatment of exacerbations of chronic bronchitis with ampicillin.用氨苄西林治疗慢性支气管炎急性加重期。
Br Med J. 1962 Dec 22;2(5320):1641-5. doi: 10.1136/bmj.2.5320.1641.
4
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Br Med J. 1961 Jul 22;2(5246):191-6. doi: 10.1136/bmj.2.5246.191.
5
Trimethoprim: laboratory and clinical studies.甲氧苄啶：实验室研究与临床研究
J Clin Pathol. 1968 Mar;21(2):202-9. doi: 10.1136/jcp.21.2.202.
6
The place of cephalexin in general medicine.
Postgrad Med J. 1970 Oct:Suppl:146-9.
7
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Antimicrob Agents Chemother (Bethesda). 1965;5:610-7.
8
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Acta Pharmacol Toxicol (Copenh). 1971;29 Suppl 3:288-303. doi: 10.1111/j.1600-0773.1971.tb03308.x.
9
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