Cowen K S, Sakamoto M, Sakamoto S
Biochem Int. 1985 Sep;11(3):273-80.
Monensin, a monovalent cation ionophore, inhibited collagenase production in mouse osteoblast-rich bone cell and clonal osteogenic cell cultures. Inhibition of parathyroid hormone-stimulated bone resorption by monensin was also studied in calvaria cultures. Collagenase activity levels in the medium decreased concomitantly with the inhibition of bone resorption by monensin, indicating that monensin inhibited bone resorption by blocking collagenase secretion from osteoblasts in bone explants.
莫能菌素是一种单价阳离子离子载体，它能抑制富含小鼠成骨细胞的骨细胞和克隆性成骨细胞培养物中胶原酶的产生。在颅盖骨培养物中也研究了莫能菌素对甲状旁腺激素刺激的骨吸收的抑制作用。培养基中的胶原酶活性水平随着莫能菌素对骨吸收的抑制而相应降低，这表明莫能菌素通过阻断骨外植体中成骨细胞的胶原酶分泌来抑制骨吸收。
