Z型的聚（dG-dC）抑制大肠杆菌DNA聚合酶I和禽成髓细胞瘤病毒DNA聚合酶的活性。

Poly(dG-dC) in the Z-form inhibits E. coli DNA polymerase I and AMV DNA polymerase activity.

作者信息

Brahmachari S K, Ramesh N, Das M R, Parnaik V K

出版信息

Biochem Int. 1985 Sep;11(3):281-90.

Abstract

The effect of Z-conformation of DNA on its template activity in DNA synthesis reactions in vitro has been studied. Normal poly(dG-dC) in the B-form, brominated and unbrominated in the Z-form have been compared for their template activity in DNA synthesis reactions mediated by AMV DNA polymerase and E. coli DNA polymerase I. The results indicate that poly(dG-dC) in the Z-form is totally inactive as a template for DNA synthesis and further that it is a strong competitive inhibitor of copying of the B-form DNA.

摘要

研究了DNA的Z构象对其体外DNA合成反应中模板活性的影响。比较了B型的正常聚（dG-dC）、Z型的溴化和未溴化聚（dG-dC）在禽成髓细胞瘤病毒DNA聚合酶和大肠杆菌DNA聚合酶I介导的DNA合成反应中的模板活性。结果表明，Z型聚（dG-dC）作为DNA合成模板完全无活性，而且它是B型DNA复制的强竞争性抑制剂。

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