Suzuki M, Tada M
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Biochem Mol Biol Int. 1993 May;30(1):73-82.
Reactions between the chemical carcinogen 4-hydroxyaminoquinoline 1-oxide (4HAQO) and poly(dG-dC).poly(dG-dC), poly(dG-m5dC).poly(dG-m5dC) and poly(dG-br5dC).poly(dG-br5dC) were studied under B-form and Z-form conformation conditions. 4HAQO bound covalently to both B-form and Z-form-DNA. The extent of the B-form to Z-form-DNA transition was diminished by 4HAQO, as inferred by spectroscopic methods. Moreover, conversion of the Z-form-DNA back to a right handed DNA close to the B-form was observed with this carcinogen.
在B型和Z型构象条件下，研究了化学致癌物4-羟基氨基喹啉1-氧化物（4HAQO）与聚（dG-dC）·聚（dG-dC）、聚（dG-m5dC）·聚（dG-m5dC）和聚（dG-br5dC）·聚（dG-br5dC）之间的反应。4HAQO与B型和Z型DNA均共价结合。通过光谱法推断，4HAQO使B型向Z型DNA转变的程度降低。此外，用这种致癌物可观察到Z型DNA转变回接近B型的右手螺旋DNA。
