Bond Emily Claire, Oliphant Rosalind Yvonne Kirton
Ferndene, Child and Young People's Inpatient Unit, Moor Road, Prudhoe, Northumberland NE42 5PB, UK.
Case Rep Psychiatry. 2018 Jun 7;2018:5049818. doi: 10.1155/2018/5049818. eCollection 2018.
Pervasive Refusal Syndrome (PRS) is a rare child psychiatric condition. We describe a case of PRS in a 9-year-old boy with a diagnosis of Autism Spectrum Disorder (ASD) presenting with severe weight loss due to extreme restriction of food and fluids. Other prominent symptoms included total mutism, school refusal, and self-neglect. He was admitted to a specialist Child and Adolescent Mental Health Unit. We discuss the symptoms present in this case and the differential diagnosis of ASD in PRS. Although this differential has briefly been considered one in previous case, there have been no reported cases of PRS with a prior diagnosis of ASD. We explore comorbidity and interaction of the two diagnoses. We discuss the possible impact of ASD as a predisposing factor upon the progression and prognosis of PRS.
广泛性拒绝综合征（PRS）是一种罕见的儿童精神疾病。我们描述了一名9岁男孩的PRS病例，该男孩被诊断为自闭症谱系障碍（ASD），因极度限制食物和液体摄入而出现严重体重减轻。其他突出症状包括完全缄默、拒绝上学和自我忽视。他被收治到一家儿童和青少年精神卫生专科病房。我们讨论了该病例中出现的症状以及PRS中ASD的鉴别诊断。尽管在之前的病例中曾简要考虑过这种鉴别，但尚无先前诊断为ASD的PRS病例报告。我们探讨了这两种诊断的共病情况和相互作用。我们讨论了ASD作为一个易感因素对PRS进展和预后的可能影响。
