Omotoso Gabriel Olaiya, Gbadamosi Ismail Temitayo, Afolabi Theresa Titilayo, Abdulwahab Ahmad Bolakale, Akinlolu Adelaja Abdulazeez
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Anat Cell Biol. 2018 Jun;51(2):119-127. doi: 10.5115/acb.2018.51.2.119. Epub 2018 Jun 27.
Cuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple sclerosis in which oxidative stress has been documented as one of the cascade in the pathogenesis. is a phytomedicinal plant with antioxidant and neuroprotective properties. This study aimed at evaluating the ameliorative capability of in cuprizone-induced behavioral and histopathological alterations in the prefrontal cortex and hippocampus of Wistar rats. Four groups of rats were treated with normal saline, cuprizone, and a combination of and cuprizone, for five weeks. The rats were subjected to Morris water maze and Y-maze to assess long and short-term memory respectively. The animals were sacrificed, and brain tissues were removed for histochemical and enzyme lysate immunosorbent assay for catalase, superoxide dismutase, and nitric oxide. Cuprizone significantly induced oxidative and nitrosative stress coupled with memory decline and cortico-hippocampal neuronal deficits; however, administration of significantly reversed the neuropathological deficits induced by cuprizone.
曲吡酮是一种具有铜螯合能力的神经毒素，用于多发性硬化症动物模型，其中氧化应激已被证明是发病机制中的级联反应之一。[植物名称]是一种具有抗氧化和神经保护特性的植物药。本研究旨在评估[植物名称]对曲吡酮诱导的Wistar大鼠前额叶皮质和海马行为及组织病理学改变的改善能力。四组大鼠分别用生理盐水、曲吡酮、[植物名称]以及[植物名称]与曲吡酮的组合进行处理，持续五周。分别对大鼠进行莫里斯水迷宫和Y迷宫实验，以评估长期和短期记忆。处死动物后，取出脑组织进行组织化学分析以及过氧化氢酶、超氧化物歧化酶和一氧化氮的酶裂解物免疫吸附测定。曲吡酮显著诱导氧化和亚硝化应激，同时伴有记忆衰退和皮质-海马神经元缺陷；然而，给予[植物名称]可显著逆转曲吡酮诱导的神经病理学缺陷。
