Mullaguri Naresh, Battineni Anusha, Narayan Aarti, Guddeti Raviteja
Neurology, Cleveland Clinic Foundation, Cleveland, USA.
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Cureus. 2018 May 4;10(5):e2576. doi: 10.7759/cureus.2576.
Cocaine is one of the most commonly abused recreational drugs, second only to marijuana. It blocks the reuptake of neurotransmitters such as norepinephrine and dopamine, that leads to persistent post-synaptic stimulation responsible for its excitatory effects. Cocaine-related strokes, both ischemic and hemorrhagic, have been well described in the literature and cerebral vasospasm is hypothesized as one of the major mechanisms responsible for the presentation. Although cases of posterior circulation infarction were previously reported, we herein report a rare presentation of a cocaine-induced bilateral posterior inferior cerebellar artery and hippocampal infarction in a middle-aged female.
可卡因是最常被滥用的消遣性药物之一,仅次于大麻。它会阻止去甲肾上腺素和多巴胺等神经递质的再摄取,从而导致持续的突触后刺激,产生兴奋作用。文献中已对可卡因相关的缺血性和出血性中风进行了充分描述,脑血管痉挛被认为是导致这种症状的主要机制之一。尽管之前有后循环梗死病例的报道,但我们在此报告一例中年女性因可卡因诱发双侧小脑后下动脉和海马梗死的罕见病例。