Haut Marc W, Hogg Jeffery P, Marshalek Patrick J, Suter Blair C, Miller Liv E
Department of Behavioral Medicine and Psychiatry, West Virginia University School of Medicine, Morgantown, WV, USA; Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA; Department of Radiology, West Virginia University School of Medicine, Morgantown, WV, USA.
Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA; Department of Radiology, West Virginia University School of Medicine, Morgantown, WV, USA.
Front Neurol. 2017 Feb 8;8:27. doi: 10.3389/fneur.2017.00027. eCollection 2017.
We report a case of a 55-year-old man with ischemic lesions of the bilateral hippocampus and bilateral basal ganglia following a myocardial infarction during an episode of multiple drug use with subsequent anoxia requiring resuscitation. He presented for a neuropsychological evaluation with an anterograde amnesia for both explicit and procedural memory. There are two main points to this case, the unique aspects of the bilateral multifocal lesions and the functional, cognitive impact of these lesions. We hypothesize that his rare focal bilateral lesions of both the hippocampus and basal ganglia are a result of anoxia acting in synergy with his stimulant drug use (cocaine and/or 3,4-methylenedioxy-methamphetamine). Second, his unique lesions produced an explicit and implicit/procedural anterograde amnesia.
我们报告一例55岁男性，在一次多种药物使用发作期间发生心肌梗死后出现双侧海马和双侧基底节缺血性病变，随后出现缺氧需要复苏。他因顺行性遗忘接受神经心理学评估，包括陈述性记忆和程序性记忆。该病例有两个要点，即双侧多灶性病变的独特方面以及这些病变对功能和认知的影响。我们推测，他海马和基底节罕见的局灶性双侧病变是缺氧与他使用兴奋剂药物（可卡因和/或3,4-亚甲基二氧甲基苯丙胺）协同作用的结果。其次，他独特的病变导致了陈述性和内隐/程序性顺行性遗忘。
