以及[具体植物名称1]、[具体植物名称2]和[具体植物名称3]提取物的抗糖尿病作用。 你提供的原文中植物名称部分缺失，以上是补充完整植物名称后的译文示例，你可根据实际情况修改。
and antidiabetic effect of extracts of , and .
作者信息
Khan Mohammad Faheem, Rawat Arun Kumar, Khatoon Shahnaaz, Hussain Mohd Kamil, Mishra Arvind, Negi Devendra Singh
机构信息
Department of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, India.
Biochemistry Division, CSIR-Central Drug Research Institute, CSIR, Lucknow, India.
出版信息
Integr Med Res. 2018 Jun;7(2):176-183. doi: 10.1016/j.imr.2018.03.004. Epub 2018 Mar 27.
BACKGROUND
To investigate the antidiabetic effect of Himalayan Medicinal plants from India viz (Family: Meliaceae), (Family: Rutaceae), (Family: Asteraceae) using as well as approaches.
METHODS
Their effects were examined on stimulation of glucose uptake by C2C12 cultured cell line, inhibitory effect on human recombinant Protein tyrosine phosphatase-1B (PTP-1B) and followed by the hypoglycaemic activity of extracts in Streptozotocin (STZ) induced diabetic rats.
RESULTS
All prepared extracts had been found to enrich with polyphenolic, flavonoids, terpenoids, anthraquinones and saponins type of compounds. -Butanol fraction of showed maximum PTP-1B inhibition (61.9%) whereas ethanol extract of showed strong stimulation of glucose uptake (+61.2%) in C2Cl2 myotubes. In STZ induced Sprague-Dawley rats, significant decrease in blood glucose level was observed in ethanol extract of treated group as 14.8% (p < 0.01) whereas in the ethanol extract of treated group, it was observed as 15.5% (p < 0.01) compare to metformin which showed 26.8% (p < 0.01) lowering of blood glucose in the same time duration of 5 h study.
CONCLUSION
This study demonstrated that these plants have a significant therapeutic value in type-2-diabetes mellitus and related complications thus supporting their traditional uses in Indian traditional system of medicine.
背景
采用体外及体内方法研究来自印度的喜马拉雅药用植物（楝科）、（芸香科）、（菊科）的抗糖尿病作用。
方法
检测它们对C2C12培养细胞系葡萄糖摄取的刺激作用、对人重组蛋白酪氨酸磷酸酶-1B（PTP-1B）的抑制作用，随后检测提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖活性。
结果
所有制备的提取物均富含多酚、黄酮类、萜类、蒽醌类和皂苷类化合物。的正丁醇部位显示出最大的PTP-1B抑制率（61.9%），而的乙醇提取物在C2Cl2肌管中显示出强烈的葡萄糖摄取刺激作用（+61.2%）。在STZ诱导的Sprague-Dawley大鼠中，与二甲双胍在5小时研究的相同时间段内血糖降低26.8%（p<0.01）相比，处理组的乙醇提取物使血糖水平显著降低14.8%（p<0.01），而处理组的乙醇提取物使血糖水平显著降低15.5%（p<0.01）。
结论
本研究表明这些植物在2型糖尿病及其相关并发症方面具有显著的治疗价值，从而支持了它们在印度传统医学体系中的传统用途。
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