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Vismodegib-resistant basal cell carcinomas in basal cell nevus syndrome: Clinical approach and genetic analysis.

作者信息

Sinx Kelly A E, Roemen Guido M J M, van Zutven Virrie, Janssen Renske, Speel Ernst-Jan M, Steijlen Peter M, van Geel Michel, Mosterd Klara

机构信息

Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.

GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

出版信息

JAAD Case Rep. 2018 Apr 30;4(5):408-411. doi: 10.1016/j.jdcr.2017.11.011. eCollection 2018 Jun.

DOI:10.1016/j.jdcr.2017.11.011
PMID:29984265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6031482/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2a/6031482/7c21eb50ae7a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2a/6031482/7c21eb50ae7a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd2a/6031482/7c21eb50ae7a/gr1.jpg

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Two intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas (MIKIE): a randomised, regimen-controlled, double-blind, phase 2 trial.两种间断维莫德吉给药方案治疗多发性基底细胞癌患者（MIKIE）：一项随机、方案对照、双盲、2 期试验。
Lancet Oncol. 2017 Mar;18(3):404-412. doi: 10.1016/S1470-2045(17)30072-4. Epub 2017 Feb 8.
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Inhibition of the hedgehog pathway in patients with basal-cell nevus syndrome: final results from the multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.基底细胞痣综合征患者中 hedgehog 通路的抑制：多中心、随机、双盲、安慰剂对照、2 期临床试验的最终结果。
Lancet Oncol. 2016 Dec;17(12):1720-1731. doi: 10.1016/S1470-2045(16)30566-6. Epub 2016 Nov 10.
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Personalized Systemic Therapies in Hereditary Cancer Syndromes.
遗传性癌症综合征中的个体化系统治疗。
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Patched Homolog 1 (PTCH1) Mutation in a CIC-Rearranged Sarcoma: Lack of Response to the Smoothened (SMO) Vismodegib.一种CIC重排肉瘤中的patched同源物1（PTCH1）突变：对Smoothened（SMO）抑制剂维莫德吉无反应。
Cureus. 2023 Jan 27;15(1):e34281. doi: 10.7759/cureus.34281. eCollection 2023 Jan.
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Novel Approaches in Non-Melanoma Skin Cancers-A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC).新型非黑色素瘤皮肤癌治疗方法——聚焦基底细胞癌中的 Hedgehog 通路
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