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雌激素受体β和 Ki67 在前列腺腺癌中的共表达作用。

Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma.

机构信息

Department of Pathobiology and Medical Diagnostic, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Sabah, Malaysia.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Sabah, Malaysia.

出版信息

Investig Clin Urol. 2018 Jul;59(4):232-237. doi: 10.4111/icu.2018.59.4.232. Epub 2018 Jun 18.

DOI:10.4111/icu.2018.59.4.232
PMID:29984337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6028465/
Abstract

PURPOSE

To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship.

MATERIALS AND METHODS

We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and Ki67 was analyzed according to Gleason score categorized into prognostic groups of 1 to 5. Double-immunofluorescent staining of ER-beta and Ki67 was performed in a total of 20 cases to study the co-expression and the relationship between these markers within the same tumor.

RESULTS

A total of 53 of 101 cases (52.5%) were positive for ER-beta expression. There was a positive correlation whereby a high percentage of ER-beta expression was seen in the higher prognostic groups (groups 4 and 5; p=0.007). High Ki67 expression was observed in the higher prognostic group, whereas low Ki67 or negative expression was found in the lower prognostic group (p<0.001). The majority of cases evaluated with double-immunofluorescent staining (14/20) showed co-expression of ER-beta and Ki67 at the individual cell level.

CONCLUSIONS

ER-beta and Ki67 are independent tumor markers in high prognostic groups. Hence, co-expression of ER-beta and Ki67 indicates a more aggressive tumor with a poorer prognosis.

摘要

目的

评估前列腺癌中雌激素受体（ER）-β和 Ki67 的表达并研究它们之间的关系。

材料与方法

我们分析了 100 例患者中 101 例 2011 年 1 月至 2015 年 6 月期间诊断为前列腺腺癌的病例。根据 Gleason 评分将 ER-β和 Ki67 的免疫组织化学染色结果分为预后 1-5 组。对总共 20 例进行 ER-β和 Ki67 的双重免疫荧光染色，以研究这些标志物在同一肿瘤中的共表达及其相关性。

结果

101 例中有 53 例（52.5%）ER-β表达阳性。高比例的 ER-β表达与较高的预后组（第 4 组和第 5 组；p=0.007）呈正相关。高 Ki67 表达见于预后较高的组，而低 Ki67 或阴性表达见于预后较低的组（p<0.001）。在进行双重免疫荧光染色的大多数病例（14/20）中，在单个细胞水平上显示 ER-β和 Ki67 的共表达。

结论

ER-β和 Ki67 是高预后组中的独立肿瘤标志物。因此，ER-β和 Ki67 的共表达表明肿瘤侵袭性更强，预后更差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/ed2e101ba59e/icu-59-232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/f45c466a93b2/icu-59-232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/0df18f4ecace/icu-59-232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/71329de31819/icu-59-232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/ed2e101ba59e/icu-59-232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/f45c466a93b2/icu-59-232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/0df18f4ecace/icu-59-232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/71329de31819/icu-59-232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3aa/6028465/ed2e101ba59e/icu-59-232-g006.jpg

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Current concepts and significance of estrogen receptor β in prostate cancer.当前前列腺癌中雌激素受体 β 的概念和意义。
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