Bera Kinjal N, Yadav Shakti K, Prakash Om, Singh Sompal, Sarin Namrata
Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India.
Department of Urology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, Delhi, India.
Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S30-S33. doi: 10.4103/IJPM.IJPM_467_18.
The roles of estrogen and progesterone in human prostate carcinogenesis have been only recently recognized.
This study was conducted to evaluate the expressions of esterone receptor-beta (ER-β), progesterone receptor (PR), and Ki-67 in benign and malignant lesions of the prostate.
The study was conducted at a tertiary care hospital. It was an analytical cross-sectional study.
We selected a total of 39 cases including 26 cases of benign prostatic hyperplasia and 13 cases of adenocarcinoma prostate. The proportion of cases showing expression for ER-β, PR, and Ki-67 was noted for both groups. A difference in immunoexpression between benign and malignant cases was evaluated. Association between receptor expression and Gleason grade was evaluated for malignant cases.
To compare the difference in expressions of ER-β, PR, and Ki-67 Mann-Whitney U test was used. Association between ER-β, PR, and Ki-67 expression and Gleason grade was analyzed using the Chi-square test.
ER-β expression was seen in all benign and malignant cases, whereas the majority of the malignant cases (61.54%) were negative for progesterone expression. Epithelial expressions of ER-β and PR were significantly higher in benign as compared with malignant lesions. Malignant cases showed a significantly higher expression of Ki-67. However, we did not find any association between the expressions of these markers with Gleason grade.
The expressions of ER-β and PR were significantly higher in the epithelium in benign cases as compared with malignant cases. Ki-67 expression was significantly higher in the malignant group as compared with the benign group.
雌激素和孕激素在人类前列腺癌发生中的作用直到最近才被认识到。
本研究旨在评估雌激素受体-β（ER-β）、孕激素受体（PR）和Ki-67在前列腺良性和恶性病变中的表达。
该研究在一家三级医疗医院进行。这是一项分析性横断面研究。
我们共选取了39例病例，其中包括26例良性前列腺增生和13例前列腺腺癌。记录两组中显示ER-β、PR和Ki-67表达的病例比例。评估良性和恶性病例之间免疫表达的差异。评估恶性病例中受体表达与 Gleason 分级之间的关联。
采用Mann-Whitney U检验比较ER-β、PR和Ki-67表达的差异。使用卡方检验分析ER-β、PR和Ki-67表达与Gleason分级之间的关联。
所有良性和恶性病例均可见ER-β表达，但大多数恶性病例（61.54%）孕激素表达为阴性。与恶性病变相比，良性病变中ER-β和PR的上皮表达明显更高。恶性病例Ki-67表达明显更高。然而,我们未发现这些标志物表达与Gleason分级之间存在任何关联.
与恶性病例相比，良性病例上皮中ER-β和PR表达明显更高,与良性组相比，恶性组Ki-67表达明显更高。
