Safeek Rachel H, Hall Katherine S, Lobelo Felipe, Del Rio Carlos, Khoury Audrey L, Wong Tammy, Morey Miriam C, McKellar Mehri S
1 Center for AIDS Research at Emory University, Emory University School of Medicine , Atlanta, Georgia .
2 Division of Geriatrics, Department of Medicine, Duke University Medical Center , Durham, North Carolina.
AIDS Res Hum Retroviruses. 2018 Nov;34(11):929-935. doi: 10.1089/AID.2017.0309. Epub 2018 Sep 20.
Antiretroviral therapy (ART) has prolonged lives of persons living with HIV/AIDS (PLWHA), resulting in greater incidence of aging-related diseases and disability. Physical activity (PA) is recommended for healthy aging, but little is known about PA in older PLWHA. The purpose of this study was to objectively assess PA levels in older PLWHA and the associations with physical function. Twenty-one PLWHA, ≥50 years old, on ART with undetectable HIV-1 viral loads, wore an accelerometer to assess PA, including number of steps, activity intensity, and energy expenditure over 7 days. A physical function performance battery assessing aerobic capacity, strength, and gait speed was also completed. Average age was 66, and 67% were male. An average of 3,442 (interquartile range: 4,613) steps were walked daily, with 254.9 kcals expended. Participants spent most waking hours (75%) sedentary, with minimal hours (24%) in light-intensity activity. Only 5 min per day (35 min per week), on average, were spent in moderate-to-vigorous physical activity (MVPA). Maximal gait speed and 6-min walk test significantly correlated (p < .05) with all PA outcomes. Usual gait speed significantly correlated with all PA outcomes, except for daily kcals and light-intensity activity. Greater PA was associated with better physical performance, while high sedentary time was associated with poorer performance. To our knowledge, this is the first study to objectively measure PA in older PLWHA. Our findings indicate that older PLWHA accumulate substantial sedentary time. Most (86%) do not achieve recommended MVPA levels. This activity profile was associated with poor physical function. Providers should promote PA among PLWHA.
抗逆转录病毒疗法（ART）延长了艾滋病毒/艾滋病感染者（PLWHA）的寿命，导致与衰老相关疾病和残疾的发病率更高。体育活动（PA）被推荐用于健康老龄化，但对于老年PLWHA的体育活动情况知之甚少。本研究的目的是客观评估老年PLWHA的体育活动水平及其与身体功能的关联。21名年龄≥50岁、接受ART且HIV-1病毒载量检测不到的PLWHA佩戴加速度计，以评估7天内的体育活动情况，包括步数、活动强度和能量消耗。还完成了一项评估有氧能力、力量和步速的身体功能表现测试。平均年龄为66岁，67%为男性。每天平均步行3442步（四分位距：4613步），消耗254.9千卡热量。参与者醒着的大部分时间（75%）处于久坐状态，轻度活动时间最少（24%）。平均每天仅5分钟（每周35分钟）用于中等至剧烈体育活动（MVPA）。最大步速和6分钟步行测试与所有体育活动结果均显著相关（p<0.05）。通常步速与除每日千卡热量和轻度活动外的所有体育活动结果均显著相关。更多的体育活动与更好的身体表现相关，而高久坐时间与较差的表现相关。据我们所知，这是第一项客观测量老年PLWHA体育活动的研究。我们的研究结果表明，老年PLWHA久坐时间很长。大多数人（86%）未达到推荐的MVPA水平。这种活动模式与身体功能不佳有关。医疗服务提供者应在PLWHA中推广体育活动。
