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自闭症病理生理学和治疗新进展概述。

Overview of the Recent Advances in Pathophysiology and Treatment for Autism.

机构信息

Physiology Department, Tehran University of Medical Sciences-International Campus, Tehran, Iran.

Physiology Department, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

CNS Neurol Disord Drug Targets. 2018;17(8):590-594. doi: 10.2174/1871527317666180706141654.

Abstract

BACKGROUND & OBJECTIVE: Autism is a developmental disorder that manifests itself in early childhood. Autism is characterized by inability to acquire social skills, repetitive behaviors and failure of speech and nonverbal communication development. Recent studies have shown that genetic mutations occur in majority of individuals with autism. These mutations cause a variety of disorders that ultimately lead to brain disorders. It is noteworthy that all mutations do not follow the same pattern. They encompass various kinds of mutations. Autism needs to be treated during childhood as untreated patients usually do not progress to the later stages of development. In this regard, many studies have been performed and numerous treatments have been proposed to improve the outcome of this disease.

CONCLUSION

In this review, we have discussed new advancements made in understanding the pathophysiology of autism. Furthermore, we have also discussed new treatments which have been proposed and have successfully translated affected children. Overall, it is concluded that new advances have largely helped these patients.

摘要

背景与目的

自闭症是一种在儿童早期表现出来的发育障碍。自闭症的特征是无法获得社交技能、重复行为以及言语和非言语沟通发育失败。最近的研究表明,大多数自闭症患者都存在基因突变。这些突变导致了各种紊乱,最终导致了大脑紊乱。值得注意的是,并非所有的突变都遵循相同的模式。它们包含各种类型的突变。自闭症需要在儿童时期进行治疗,因为未经治疗的患者通常不会发展到发育的后期阶段。在这方面,已经进行了许多研究,并提出了许多治疗方法来改善这种疾病的结果。

结论

在这篇综述中,我们讨论了在理解自闭症的病理生理学方面取得的新进展。此外,我们还讨论了已经提出并成功转化受影响儿童的新治疗方法。总的来说,新的进展在很大程度上帮助了这些患者。

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