Puglsey T A, Lippmann W
Experientia. 1977 Jan 15;33(1):57-9. doi: 10.1007/BF01936753.
A new series of compounds structurally related to the potential antidepressant tandamine, i.e., the 1-alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines, inhibit the noradrenaline uptake mechanism and are relatively ineffective in inhibiting the serotonin uptake mechanism in vivo. The potency of the most effective compound (9-ethyl-N,N,1-trimethyl-1,2,3,4-tetrahydrocarbazole) is similar to that of desimipramine and is of potential use in the treatment of endogenously depressed patients.
一系列结构上与潜在抗抑郁药坦达明相关的新化合物，即1-烷基-1,2,3,4-四氢咔唑-1-乙胺，可抑制去甲肾上腺素摄取机制，且在体内抑制5-羟色胺摄取机制方面相对无效。最有效化合物（9-乙基-N,N,1-三甲基-1,2,3,4-四氢咔唑）的效力与地昔帕明相似，具有治疗内源性抑郁症患者的潜在用途。
